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eif-2Balpha putative translation initiation factor eIF-2B subunit alpha [ Caenorhabditis elegans ]

Gene ID: 176348, updated on 23-Nov-2023

Summary

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Gene symbol
eif-2Balpha
Gene description
putative translation initiation factor eIF-2B subunit alpha
Primary source
WormBase:WBGene00014221
Locus tag
CELE_ZK1098.4
See related
AllianceGenome:WB:WBGene00014221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables identical protein binding activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (9543119..9544404)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Exonuclease mut-7 Neighboring gene Uncharacterized protein Neighboring gene DUF2975 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Matthews LR, et al. Genome Res, 2001 Dec. PMID 11731503, Free PMC Article
  2. A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome. Davy A, et al. EMBO Rep, 2001 Sep. PMID 11559592, Free PMC Article
  3. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative translation initiation factor eIF-2B subunit alpha
NP_499106.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9543119..9544404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066705.6 → NP_499106.1  putative translation initiation factor eIF-2B subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499106.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34604
    Conserved Domains (2) summary
    COG1184
    Location:1 → 304
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:15 → 293
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34604.1

Gene LinkOut

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