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eif-3.D Eukaryotic translation initiation factor 3 subunit D [ Caenorhabditis elegans ]

Gene ID: 176268, updated on 5-May-2024

Summary

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Gene symbol
eif-3.D
Gene description
Eukaryotic translation initiation factor 3 subunit D
Primary source
WormBase:WBGene00001227
Locus tag
CELE_R08D7.3
See related
AllianceGenome:WB:WBGene00001227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is expressed in pharynx. Orthologous to human EIF3D (eukaryotic translation initiation factor 3 subunit D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (8969635..8971578, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GRound-Like (grd related) Neighboring gene ncRNA Neighboring gene BUD13 homolog Neighboring gene Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2 Neighboring gene Complex 1 LYR protein domain-containing protein;Complex1_LYR_dom domain-containing protein Neighboring gene putative calcium-binding protein R08D7.5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. Asano K, et al. J Biol Chem, 1997 Oct 24. PMID 9341143
  2. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article
  3. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
  4. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA cap binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cap-dependent translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Eukaryotic translation initiation factor 3 subunit D
NP_498984.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8969635..8971578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066583.7 → NP_498984.1  Eukaryotic translation initiation factor 3 subunit D [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498984.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30642
    Conserved Domains (1) summary
    pfam05091
    Location:6 → 548
    eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30642.1

Gene LinkOut

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