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egl-45 Eukaryotic translation initiation factor 3 subunit A [ Caenorhabditis elegans ]

Gene ID: 176094, updated on 5-May-2024

Summary

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Gene symbol
egl-45
Gene description
Eukaryotic translation initiation factor 3 subunit A
Primary source
WormBase:WBGene00001209
Locus tag
CELE_C27D11.1
See related
AllianceGenome:WB:WBGene00001209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity and translation regulator activity. Predicted to contribute to translation initiation factor activity. Involved in embryo development and oviposition. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3e; eukaryotic translation initiation factor 3 complex, eIF3m; and multi-eIF complex. Is expressed in neurons. Orthologous to human EIF3A (eukaryotic translation initiation factor 3 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (7824377..7828626, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homeobox protein egl-5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Drought induced 19 protein type zinc-binding domain-containing protein;zf-Di19 domain-containing protein Neighboring gene Homeobox protein ceh-23

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A unified mode of epigenetic gene silencing: RNA meets polycomb group proteins. Sun Y, et al. RNA Biol, 2005 Jan. PMID 17132931
  2. Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying. Desai C, et al. Genetics, 1989 Apr. PMID 2721931, Free PMC Article
  3. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Wilson R, et al. Nature, 1994 Mar 3. PMID 7906398
  4. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Gönczy P, et al. Nature, 2000 Nov 16. PMID 11099034
  5. A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Desai C, et al. Nature, 1988 Dec 15. PMID 3200316

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3e IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 3 subunit A
NP_498698.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7824377..7828626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066297.7 → NP_498698.1  Eukaryotic translation initiation factor 3 subunit A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498698.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34339
    Conserved Domains (3) summary
    smart00753
    Location:431 → 502
    PAM; PCI/PINT associated module
    cd16269
    Location:670 → 687
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:608 → 706
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34339.1

Gene LinkOut

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