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rpn-6.1 putative 26S proteasome regulatory subunit rpn-6.1 [ Caenorhabditis elegans ]

Gene ID: 175972, updated on 5-May-2024

Summary

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Gene symbol
rpn-6.1
Gene description
putative 26S proteasome regulatory subunit rpn-6.1
Primary source
WormBase:WBGene00004462
Locus tag
CELE_F57B9.10
See related
AllianceGenome:WB:WBGene00004462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable structural molecule activity. Involved in determination of adult lifespan; proteasome assembly; and ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in intestine and pharynx. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (6959110..6962001, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene CCR4-NOT transcription complex subunit let-711 Neighboring gene Putative pyridoxamine 5'-phosphate oxidase Neighboring gene PAN (PolyA-specific riboNucLease) subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis. Ravichandran M, et al. Cell Metab, 2018 Apr 3. PMID 29551589
  2. n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease. Fu RH, et al. PLoS One, 2014. PMID 24416384, Free PMC Article
  3. RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Vilchez D, et al. Nature, 2012 Sep 13. PMID 22922647
  4. UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. MacMorris M, et al. RNA, 2003 Jul. PMID 12810918, Free PMC Article
  5. Reversible 26S proteasome disassembly upon mitochondrial stress. Livnat-Levanon N, et al. Cell Rep, 2014 Jun 12. PMID 24857655

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome accessory complex TAS
Traceable Author Statement
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative 26S proteasome regulatory subunit rpn-6.1
NP_001022621.1
  • Confirmed by transcript evidence
NP_001022622.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6959110..6962001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027450.5 → NP_001022621.1  putative 26S proteasome regulatory subunit rpn-6.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022621.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20938, Q5DX45
    Conserved Domains (2) summary
    COG5159
    Location:19 → 435
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:311 → 405
    PCI; PCI domain

  2. NM_001027451.6 → NP_001022622.1  putative 26S proteasome regulatory subunit rpn-6.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022622.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20938
    Conserved Domains (2) summary
    COG5159
    Location:1 → 417
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:293 → 387
    PCI; PCI domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20938.2

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