atgl-1 PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: atgl-1
Gene description: PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1
Primary source: WormBase:WBGene00015484
Locus tag: CELE_C05D11.7
See related: AllianceGenome:WB:WBGene00015484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Located in lipid droplet. Is expressed in several structures, including body wall musculature; intestine; nervous system; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 10; coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including PNPLA2 (patatin like phospholipase domain containing 2) and PNPLA3 (patatin like phospholipase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (6415772..6419459, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Over-expression of ATGL-1 extends lifespan while loss-of-function mutant decreases lifespan of long-lived C. elegans models.
Title: ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans.
In the intestinal cells of C. elegans, a newly identified protein, lipid droplet protein 1 (C25A1.12; LID-1), modulates lipolysis by binding to adipose triglyceride lipase 1 (C05D11.7; ATGL-1) during nutritional deprivation.
Title: Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D11.7 (e-PCR)
- UniSTS:308937

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables triglyceride lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triglyceride lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1

NP_741195.1

Confirmed by transcript evidence

NP_741196.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6415772..6419459 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171168.6 → NP_741196.1 Patanin-like phospholipase domain-containing protein atgl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741196.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q11186

Conserved Domains (1) summary

cd07204
Location:12 → 252

Pat_PNPLA_like; Patatin-like phospholipase domain containing protein family
NM_171167.6 → NP_741195.1 PNPLA domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741195.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T3F2

Conserved Domains (1) summary

cd07204
Location:12 → 252

Pat_PNPLA_like; Patatin-like phospholipase domain containing protein family