efk-1 Eukaryotic elongation factor 2 kinase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: efk-1
Gene description: Eukaryotic elongation factor 2 kinase
Primary source: WormBase:WBGene00001160
Locus tag: CELE_F42A10.4
See related: AllianceGenome:WB:WBGene00001160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables elongation factor-2 kinase activity. Involved in protein phosphorylation. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (6164906..6168547, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eEF2K enhances the accuracy of protein synthesis under a range of conditions and in several cell types. Activation of eEF2K decreases misreading or termination readthrough errors during elongation, whereas knocking down or knocking out eEF2K increases their frequency.
Title: Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan.
Genetic deletion of the eEF2K ortholog efk-1 reduced oxidative stress, and improved chemotaxis and serotonin sensitivity in C. elegans expressing human Abeta42 in neurons. Study highlights the potential utility of eEF2K inhibition to reduce Abeta-mediated oxidative stress in Alzheimer's disease.
Title: eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.
C. elegans strains deficient in efk-1, the eEF2K ortholog, were severely compromised in their response to nutrient depletion.
Title: The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42A10.4 (e-PCR)
- UniSTS:310269

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables elongation factor-2 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables elongation factor-2 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables elongation factor-2 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in myosin II filament disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Eukaryotic elongation factor 2 kinase

NP_001022572.1

Confirmed by transcript evidence

NP_001022573.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6164906..6168547 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027402.6 → NP_001022573.1 Eukaryotic elongation factor 2 kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022573.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01991

Conserved Domains (2) summary

smart00811
Location:106 → 301

Alpha_kinase; Alpha-kinase family

sd00010
Location:666 → 716

SLR; SLR repeat [structural motif]
NM_001027401.4 → NP_001022572.1 Eukaryotic elongation factor 2 kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022572.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01991, O01992, Q20309, Q8MYP9

Conserved Domains (2) summary

smart00811
Location:106 → 301

Alpha_kinase; Alpha-kinase family

sd00010
Location:674 → 724

SLR; SLR repeat [structural motif]