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gly-14 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [ Caenorhabditis elegans ]

Gene ID: 175453, updated on 23-Nov-2023

Summary

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Gene symbol
gly-14
Gene description
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Primary source
WormBase:WBGene00001639
Locus tag
CELE_M01F1.1
See related
AllianceGenome:WB:WBGene00001639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Involved in protein N-linked glycosylation. Located in perinuclear region of cytoplasm. Is expressed in intestine. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (3490337..3493238, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein C34C12.6 Neighboring gene Uncharacterized protein Neighboring gene Arrestin_N domain-containing protein Neighboring gene Lipoprotein;VWFD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ablation of N-acetylglucosaminyltransferases in Caenorhabditis induces expression of unusual intersected and bisected N-glycans. Yan S, et al. Biochim Biophys Acta Gen Subj, 2018 Oct. PMID 29981898, Free PMC Article
  2. The directed migration of gonadal distal tip cells in Caenorhabditis elegans requires NGAT-1, a ß1,4-N-acetylgalactosaminyltransferase enzyme. Veyhl J, et al. PLoS One, 2017. PMID 28817611, Free PMC Article
  3. Synthesis of paucimannose N-glycans by Caenorhabditis elegans requires prior actions of UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, alpha3,6-mannosidase II and a specific membrane-bound beta-N-acetylglucosaminidase. Zhang W, et al. Biochem J, 2003 May 15. PMID 12603202, Free PMC Article
  4. Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development. Chen S, et al. J Biol Chem, 1999 Jan 1. PMID 9867843
  5. N-glycans are involved in the response of Caenorhabditis elegans to bacterial pathogens. Shi H, et al. Methods Enzymol, 2006. PMID 17132514

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The gly-12 and gly-14 mutants as well as the gly-14; gly-12 double mutant all displayed wild-type phenotypes, indicating that neither gly-12 nor gly-14 is necessary for worm development.
    Title: Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity.
  2. A worm with null mutations in all three GnT I genes, gly-14, gly-12, & gly-13; worm extracts do not express GnT I activity and have a markedly abnormal N-glycan pattern.
    Title: Caenorhabditis elegans triple null mutant lacking UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in regulation of alpha-(1->3)-fucosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi medial cisterna ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NP_497719.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3490337..3493238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065318.4 → NP_497719.1  Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFK6
    Conserved Domains (1) summary
    cd02514
    Location:91 → 428
    GT13_GLCNAC-TI; GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides
Nucleotide Protein
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