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iffb-1 Eukaryotic translation initiation factor 5B [ Caenorhabditis elegans ]

Gene ID: 175353, updated on 5-May-2024

Summary

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Gene symbol
iffb-1
Gene description
Eukaryotic translation initiation factor 5B
Primary source
WormBase:WBGene00021857
Locus tag
CELE_Y54F10BM.2
See related
AllianceGenome:WB:WBGene00021857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Is expressed in germ line. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (2314436..2326901)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene Insulin/EGF-Receptor L Domain protein Neighboring gene Dual specificity protein phosphatase 19 Neighboring gene PPM-type phosphatase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B. Kim E, et al. Cell Mol Life Sci, 2018 Dec. PMID 30019215, Free PMC Article
  2. Eukaryotic translation initiation factor 5B activity regulates larval growth rate and germline development in Caenorhabditis elegans. Yu X, et al. Genesis, 2006 Sep. PMID 16937415
  3. Sperm chromatin proteomics identifies evolutionarily conserved fertility factors. Chu DS, et al. Nature, 2006 Sep 7. PMID 16943775, Free PMC Article
  4. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  5. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 5B
NP_497536.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2314436..2326901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065135.9 → NP_497536.2  Eukaryotic translation initiation factor 5B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497536.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGT7
    Conserved Domains (2) summary
    pfam15745
    Location:237 → 283
    AP1AR; AP-1 complex-associated regulatory protein
    cl30717
    Location:480 → 1073
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
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