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Mras muscle and microspikes RAS [ Mus musculus (house mouse) ]

Gene ID: 17532, updated on 4-Jan-2025

Summary

Official Symbol
Mrasprovided by MGI
Official Full Name
muscle and microspikes RASprovided by MGI
Primary source
MGI:MGI:1100856
See related
Ensembl:ENSMUSG00000032470 AllianceGenome:MGI:1100856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900078C09Rik
Summary
Predicted to enable GTP-dependent protein binding activity; GTPase activity; and guanyl ribonucleotide binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; branchial arch; future spinal cord; limb bud; and liver. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in cortex adult (RPKM 34.0), ovary adult (RPKM 30.7) and 21 other tissues See more
Orthologs
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Genomic context

See Mras in Genome Data Viewer
Location:
9 E3.3; 9 51.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99267473..99319505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99385420..99437700, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 70 Neighboring gene RIKEN cDNA 4930422M22 gene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 14 pseudogene Neighboring gene extended synaptotagmin-like protein 3 Neighboring gene STARR-seq mESC enhancer starr_25024 Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene NME/NM23 family member 9 Neighboring gene armadillo repeat containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6796

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity  
enables GDP binding  
enables GTP binding  
enables GTP binding  
enables GTP-dependent protein binding  
enables GTP-dependent protein binding  
enables GTPase activity  
enables GTPase activity  
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  
part_of protein phosphatase type 1 complex  

General protein information

Preferred Names
ras-related protein M-Ras
Names
X-Ras
ras-related protein R-Ras3
NP_032650.1
XP_006510888.1
XP_030099940.1
XP_036010535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008624.3NP_032650.1  ras-related protein M-Ras

    See identical proteins and their annotated locations for NP_032650.1

    Status: VALIDATED

    Source sequence(s)
    AB004879, AC157994, AK050469, BC023079, CJ162751, CX122916
    Consensus CDS
    CCDS23433.1
    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Related
    ENSMUSP00000035045.9, ENSMUST00000035045.15
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    99267473..99319505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510825.4XP_006510888.1  ras-related protein M-Ras isoform X1

    See identical proteins and their annotated locations for XP_006510888.1

    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Related
    ENSMUSP00000113275.2, ENSMUST00000122384.9
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  2. XM_036154642.1XP_036010535.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Related
    ENSMUSP00000112407.2, ENSMUST00000119472.8
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  3. XM_030244080.1XP_030099940.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    O08989
    UniProtKB/TrEMBL
    Q3TPX5
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
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