eif-3.B Eukaryotic translation initiation factor 3 subunit B [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: eif-3.B
Gene description: Eukaryotic translation initiation factor 3 subunit B
Primary source: WormBase:WBGene00001225
Locus tag: CELE_Y54E2A.11
See related: AllianceGenome:WB:WBGene00001225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity and translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in regulation of translational initiation and translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including anal depressor muscle; nervous system; pharynx; rectal epithelium; and reproductive system. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (14795404..14798235)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y54E2A.11 (e-PCR)
- UniSTS:313000

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 3 subunit B

NP_001022469.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14795404..14798235

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027298.8 → NP_001022469.2 Eukaryotic translation initiation factor 3 subunit B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022469.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7K785, Q9XWI6

Conserved Domains (4) summary

cd12278
Location:45 → 126

RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

pfam08662
Location:403 → 609

eIF2A; Eukaryotic translation initiation factor eIF2A

sd00039
Location:208 → 241

7WD40; WD40 repeat [structural motif]

cl02567
Location:211 → 296

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...