mecr-1 Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: mecr-1
Gene description: Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Primary source: WormBase:WBGene00012375
Locus tag: CELE_W09H1.5
See related: AllianceGenome:WB:WBGene00012375
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (13185987..13187314, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W09H1.5 (e-PCR)
- UniSTS:306100

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Enoyl-[acyl-carrier-protein] reductase, mitochondrial

NP_496800.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13185987..13187314 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064399.5 → NP_496800.1 Enoyl-[acyl-carrier-protein] reductase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496800.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45903

Conserved Domains (2) summary

cd08290
Location:17 → 343

ETR; 2-enoyl thioester reductase (ETR)

COG1064
Location:21 → 343

AdhP; D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport and metabolism]