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LMP2 EBNA3A nuclear protein [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 17494212, discontinued on 1-Mar-2018
  • This record was discontinued.

Summary

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Gene symbol
LMP2
Gene description
EBNA3A nuclear protein
Gene type
protein coding
RNA name
EBNA3A nuclear protein
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This dynamic change in B cell survival mechanisms is unique to Epstein-Barr virus-infected cells and relies on regulation of MCL-1 mitochondrial localization and BFL-1 transcription by the viral EBNA3A protein.
    Title: Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
  2. LMP1 and LMP2A collaborate to promote early-onset lymphomas in a mouse model, but neither protein is absolutely essential.
    Title: Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential.
  3. These results support a model in which EBNA2 and EBNA3s compete for distinct subsets of RBPJ sites to regulate cell genes and where EBNA3 subset specificity is determined by interactions with other cell transcription factors.
    Title: Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic Sites.
  4. LMP2A reduces the stringency of GC B-cell selection and may contribute to persistent EBV infection and pathogenesis by providing GC B cells with excessive prosurvival effects
    Title: Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A.
  5. The LMP2B isoform lacks the 19-amino acid N-terminal domain found in LMP2A, which modulates cellular signaling resulting in a baseline activation of B cells.[review]
    Title: Latent Membrane Protein 2 (LMP2).
  6. HLA Class I (HLA- A, -B, -C) antigens are downregulated by LMP2A protein in Epstein-Barr virus-infected gastric cancer cells.
    Title: Epstein-Barr virus latent membrane protein 2A mediated activation of Sonic Hedgehog pathway induces HLA class Ia downregulation in gastric cancer cells.
  7. Epstein-Barr virus nuclear antigen 3A promotes cellular proliferation by repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1
    Title: Epstein-Barr virus nuclear antigen 3A promotes cellular proliferation by repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1.
  8. find that both Syk and LMP2A have an effect on ITGbeta4 cell surface expression
    Title: SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.
  9. In the presence of EBNA3A, expression of the MIZ-1 target gene, CDKN2B, is downregulated and repressive H3K27 marks are established on its promoter region suggesting that EBNA3A directly counteracts the growth inhibitory action of MIZ-1.
    Title: Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.
  10. findings bridge the gap between the NPC-specific cell surface molecule and the final phenotype of the NPC cells. Additionally, our findings indicate that LMP2A and mTOR will serve as targets for NPC therapy in the future
    Title: Epstein-Barr virus-encoded latent membrane protein 2A promotes the epithelial-mesenchymal transition in nasopharyngeal carcinoma via metastatic tumor antigen 1 and mechanistic target of rapamycin signaling induction.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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TATA_signal

  • Loc: 101588-101593
  • Loc: 106693-106698
  • Loc: 106810-106815
  • Loc: 11305-11308
  • Loc: 125569-125574
  • Loc: 130300-130305
  • Loc: 133013-133017
  • Loc: 135432-135436
  • Loc: 136331-136336
  • Loc: 14352
  • Loc: 164979-164984
  • Loc: 165008-165013
  • Loc: 166011-166016
  • Loc: 1691-1695
  • Loc: 17424
  • Loc: 20496
  • Loc: 23568
  • Loc: 26640
  • Loc: 29712
  • Loc: 32784
  • Loc: 41471-41476
  • Loc: 46544-46549
  • Loc: 49056-49061
  • Loc: 62729
  • Loc: 63881
  • Loc: 66516-66521
  • Loc: 67552-67557
  • Loc: 68491-68496
  • Loc: 68544-68549
  • Loc: 74594-74599
  • Loc: 76219-76224
  • Loc: 76575-76580
  • Loc: 92728-92733
  • Loc: 93955-93960
  • Loc: 9631-9636
  • Loc: 97617-97621

mat_peptide

  • Loc: 116900-118060
  • Loc: 86035-86481

Miscellaneous features

  • Loc: 100332 BAM: Bam H1 K/B
  • Loc: 110025 BAM: Bam H1 B/G
  • Loc: 116560 BAM: Bam H1 G/D
  • Loc: 124580 BAM: Bam H1 D/c
  • Loc: 125730 BAM: Bam H1 c/b
  • Loc: 127063 BAM: Bam H1 b/T
  • Loc: 130451 BAM: Bam H1 T/X
  • Loc: 13215 BAM: BamH1 C/W
  • Loc: 132573 BAM: Bam H1 X/V
  • Loc: 135718 BAM: Bam H1 V/d
  • Loc: 136826 BAM: Bam H1 d/I
  • Loc: 139723->151555 DEL: B95-8 deletion with respect to Raji
  • Loc: 139724-151554 5-11835 of Raji DNA restoring the B95-8 deletion sequence
  • Loc: 143272-144328 DR right, similar to 40366..41409, ori lyt
  • Loc: 153179 HPN: 22bp 2-fold symmetric
  • Loc: 154289 BAM: Bam H1 I/A
  • Loc: 16287 BAM: BamH1 W/W
  • Loc: 166156 BAM: Bam H1 A/Nhet
  • Loc: 19359 BAM: BamH1 W/W
  • Loc: 22431 BAM: BamH1 W/W
  • Loc: 25503 BAM: BamH1 W/W
  • Loc: 28575 BAM: BamH1 W/W
  • Loc: 31647 BAM: BamH1 W/W
  • Loc: 34719 BAM: BamH1 W/Y
  • Loc: 36560 BAM: BamH1 Y/H
  • Loc: 3955 BAM: Bam H1 Nhet/h
  • Loc: 3994 BAM: Bam H1 h/C
  • Loc: 40366-41409 DRleft, similar to 143272..144328
  • Loc: 42565 BAM: BamH1 H/F
  • Loc: 49961 BAM: BamH1 F/Q
  • Loc: 50142-50189 Site III for EBNA-1 binding
  • Loc: 53833 BAM: BamH1 Q/U
  • Loc: 57122 BAM: BamH1 U/P
  • Loc: 61180 BAM: BamH1 P/O
  • Loc: 65547-65552 BAM: Bam H1 O/a
  • Loc: 6629-6795 Pol III RNA EBER 1
  • Loc: 67249-67254 BAM: Bam H1 a/M
  • Loc: 6956-7128 Pol III RNA EBER 2
  • Loc: 71945 BAM: Bam H1 M/S
  • Loc: 75362 BAM: Bam H1 S/L
  • Loc: 80415 BAM: Bam H1 L/E
  • Loc: 88325 BAM: Bam H1 E/e1
  • Loc: 88631 BAM: Bam H1 e1/e2
  • Loc: 89138 BAM: Bam H1 e2/e3
  • Loc: 89659 BAM: Bam H1 e3/Z
  • Loc: 9021-9133 HPN: dyad symmetry, site II for EBNA-1 binding;~dyad symmetry part of oriP
  • Loc: 91453 BAM: Bam H1 Z/g
  • Loc: 91528 BAM: Bam H1 g/R
  • Loc: 95169 BAM: Bam H1 R/f
  • Loc: 95277 BAM: Bam H1 f/K

polyA_signal

  • Loc: 10257-10262
  • Loc: 104497-104502
  • Loc: 108070-108075
  • Loc: 115741-115746
  • Loc: 118059-118064
  • Loc: 128681-128686
  • Loc: 134881-134886
  • Loc: 137438-137443
  • Loc: 139478-139483
  • Loc: 152796-152801
  • Loc: 160508-160513
  • Loc: 165707-165712
  • Loc: 37715-37720
  • Loc: 43230-43235
  • Loc: 49781-49786
  • Loc: 5841-5846
  • Loc: 66595-66600
  • Loc: 69892-69897
  • Loc: 75311-75316
  • Loc: 77124-77129
  • Loc: 82933-82938
  • Loc: 89477-89482
  • Loc: 93822-93827
  • Loc: 95626-95631
  • Loc: 97649-97654
  • Loc: 99431-99436
  • Loc: 99499-99504

rep_origin

  • Loc: 143207-144444
  • Loc: 40301-40656
  • Loc: 40301-41293
  • Loc: 7315-9312

Repeated regions

  • Loc: 12001-15072
  • Loc: 138947-139329
  • Loc: 140765-143281 rpt_family = PstI repeats
  • Loc: 15073-18144
  • Loc: 18145-21216
  • Loc: 21217-24288
  • Loc: 24289-27360
  • Loc: 27361-30432
  • Loc: 30433-33504
  • Loc: 33505-35355
  • Loc: 36390-36512 rpt_unit_range = 36390..36398
  • Loc: 37237-37290 rpt_unit_range = 37237..37242
  • Loc: 38290-39827 rpt_unit_range = 38290..38414
  • Loc: 57396-57642 rpt_unit_range = 57396..57446
  • Loc: 58099-58233 rpt_unit_range = 58099..58113
  • Loc: 70031-70173 rpt_unit_range = 70031..70101
  • Loc: 71352-71441 rpt_unit_range = 71352..71360
  • Loc: 7421-8042 rpt_unit_range = 7421..7450
  • Loc: 77889-78351 rpt_unit_range = 77889..77919
  • Loc: 81920-81989 rpt_family = type A
  • Loc: 81993-82018 rpt_family = type B
  • Loc: 82019-82093 rpt_family = type C
  • Loc: 82098-82123 rpt_family = type B
  • Loc: 82124-82201 rpt_family = type C
  • Loc: 82202-82272 rpt_family = type A
  • Loc: 82283-82360 rpt_family = type C
  • Loc: 82361-82431 rpt_family = type A
  • Loc: 82608-82694 rpt_family = type D
  • Loc: 82695-82781 rpt_family = type D
  • Loc: 85234-85410 rpt_unit_range = 85234..85293
  • Loc: 87834-88016 rpt_unit_range = 87834..87848
  • Loc: 88377-88493 rpt_unit_range = 88377..88415
  • Loc: 90293-90364
  • Loc: 95929-96636 rpt_family = EBNA triplet repeat GGA,GCA,GGG

variation

  • Loc: 163519-166178 replace = gg
  • Loc: 33126-40537 replace = gt
  • Loc: 33355-40163 replace = gg
  • Loc: 86838-89830 replace = gc

General protein information

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Names
EBNA3A nuclear protein
terminal protein LMP2A
terminal protein LMP2B
virion protein BBRF1
BGRF1-BDRF1 protein
putative DNA packaging protein
YP_401682.1
  • BBRF1
YP_401690.1
  • spliced BGRF1/BDRF1 reading frame

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    58..166458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401669.1 EBNA3A nuclear protein [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401669.1

    Status: PROVISIONAL

  2. YP_401631.1 terminal protein LMP2A [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401631.1

    Status: PROVISIONAL

  3. YP_401632.1 terminal protein LMP2B [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401632.1

    Status: PROVISIONAL

  4. YP_401682.1 virion protein BBRF1 [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401682.1

    Status: PROVISIONAL

  5. YP_401690.1 BGRF1-BDRF1 protein [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401690.1

    Status: PROVISIONAL

Nucleotide Protein
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Gene LinkOut

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Research Materials