rsp-1 putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rsp-1
Gene description: putative splicing factor, arginine/serine-rich 1
Primary source: WormBase:WBGene00004698
Locus tag: CELE_W02B12.3
See related: AllianceGenome:WB:WBGene00004698
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Involved in regulation of growth rate and spermatogenesis. Located in nucleus. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to several human genes including SRSF4 (serine and arginine rich splicing factor 4) and SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rsp-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (11453362..11455864)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02B12.3 (e-PCR)
- UniSTS:305993

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	NAS Non-traceable Author Statement more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative splicing factor, arginine/serine-rich 1

NP_001359656.1

Confirmed by transcript evidence

NP_001379327.1

Partially confirmed by transcript evidence

NP_496442.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11453362..11455864

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064041.5 → NP_496442.1 putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496442.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23121, Q8I106, Q8I107

Conserved Domains (3) summary

COG0724
Location:3 → 180

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12337
Location:4 → 73

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cd12600
Location:129 → 200

RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
NM_001373792.1 → NP_001359656.1 putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd12337
Location:4 → 73

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cl17169
Location:129 → 146

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001393192.1 → NP_001379327.1 putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl17169
Location:2 → 56

RRM_SF; RNA recognition motif (RRM) superfamily