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rsp-1 putative splicing factor, arginine/serine-rich 1 [ Caenorhabditis elegans ]

Gene ID: 174748, updated on 5-May-2024

Summary

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Gene symbol
rsp-1
Gene description
putative splicing factor, arginine/serine-rich 1
Primary source
WormBase:WBGene00004698
Locus tag
CELE_W02B12.3
See related
AllianceGenome:WB:WBGene00004698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Involved in regulation of growth rate and spermatogenesis. Located in nucleus. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to several human genes including SRSF4 (serine and arginine rich splicing factor 4) and SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (11453362..11455864)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lipase_GDSL domain-containing protein Neighboring gene putative splicing factor, arginine/serine-rich 2 Neighboring gene pseudo Neighboring gene Alanine--tRNA ligase, mitochondrial Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene Kinesin motor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development. Kawano T, et al. Mech Dev, 2000 Jul. PMID 10906451
  2. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article
  3. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article
  4. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  5. Functional genomics of the cilium, a sensory organelle. Blacque OE, et al. Curr Biol, 2005 May 24. PMID 15916950

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of growth rate IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative splicing factor, arginine/serine-rich 1
NP_001359656.1
  • Confirmed by transcript evidence
NP_001379327.1
  • Partially confirmed by transcript evidence
NP_496442.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11453362..11455864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064041.5 → NP_496442.1  putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496442.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23121, Q8I106, Q8I107
    Conserved Domains (3) summary
    COG0724
    Location:3 → 180
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12337
    Location:4 → 73
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:129 → 200
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

  2. NM_001373792.1 → NP_001359656.1  putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd12337
    Location:4 → 73
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cl17169
    Location:129 → 146
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001393192.1 → NP_001379327.1  putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl17169
    Location:2 → 56
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. NR_138514.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23121.1

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