C05C10.3 putative succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: C05C10.3
Gene description: putative succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial
Primary source: WormBase:WBGene00007330
Locus tag: CELE_C05C10.3
See related: AllianceGenome:WB:WBGene00007330
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3-oxoacid CoA-transferase activity. Predicted to be involved in cellular ketone body metabolic process. Located in mitochondrion. Is expressed in anal depressor muscle; body wall musculature; pharynx; and reproductive system. Orthologous to several human genes including OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (9934398..9936893, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05C10.3 (e-PCR)
- UniSTS:321185

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular ketone body metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ketone body catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial

NP_496144.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9934398..9936893 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063743.8 → NP_496144.1 putative succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496144.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09450

Conserved Domains (3) summary

COG1788
Location:37 → 273

AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

COG4670
Location:35 → 516

YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]

cl00339
Location:299 → 506

SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...