rha-1 ATP-dependent RNA helicase A;RNA helicase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rha-1
Gene description: ATP-dependent RNA helicase A;RNA helicase
Primary source: WormBase:WBGene00004355
Locus tag: CELE_T07D4.3
See related: AllianceGenome:WB:WBGene00004355
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3'-5' DNA helicase activity; double-stranded DNA binding activity; and double-stranded RNA binding activity. Involved in germ cell development and negative regulation of gene expression, epigenetic. Predicted to be located in microtubule organizing center and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleolus. Is expressed in germ line and oocyte. Orthologous to human DHX9 (DExH-box helicase 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 15

Sequence:: Chromosome: II; NC_003280.10 (8878496..8883659, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RHA-1 is a conserved transcription regulation protein that controls germline proliferation and development in C. elegans
Title: RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3079 (e-PCR)
- UniSTS:515639

T07D4.3 (e-PCR)
- UniSTS:310722

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription termination	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in intracellular anatomical structure	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP-dependent RNA helicase A;RNA helicase

NP_001360473.1

Confirmed by transcript evidence

NP_495890.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8878496..8883659 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373779.1 → NP_001360473.1 RNA helicase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WUJ5

Conserved Domains (5) summary

COG1643
Location:337 → 974

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

pfam07717
Location:1005 → 1087

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

cd19854
Location:4 → 73

DSRM_DHX9_rpt1; first double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins

cd19855
Location:169 → 244

DSRM_DHX9_rpt2; second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins

cl28899
Location:325 → 562

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_063489.6 → NP_495890.2 ATP-dependent RNA helicase A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495890.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22307

Conserved Domains (6) summary

smart00358
Location:6 → 71

DSRM; Double-stranded RNA binding motif

smart00847
Location:847 → 931

HA2; Helicase associated domain (HA2) Add an annotation

COG1643
Location:337 → 974

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd00046
Location:398 → 539

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:649 → 739

Helicase_C; Helicase conserved C-terminal domain

pfam07717
Location:971 → 1086

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold