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cpf-1 Cleavage stimulation factor 50 kDa subunit [ Caenorhabditis elegans ]

Gene ID: 174378, updated on 25-Apr-2024

Summary

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Gene symbol
cpf-1
Gene description
Cleavage stimulation factor 50 kDa subunit
Primary source
WormBase:WBGene00000773
Locus tag
CELE_F28C6.3
See related
AllianceGenome:WB:WBGene00000773
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage stimulating factor complex. Orthologous to human CSTF1 (cleavage stimulation factor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (8600449..8602440, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transcription factor aptf-4 Neighboring gene Transcription factor AP-2 C-terminal domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 2 Neighboring gene Amelotin Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL24 Neighboring gene Suppressor of forked domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extending the CRISPR toolbox for C. elegans: Cpf1 as an alternative gene editing system for AT-rich sequences. Ebbing A, et al. MicroPubl Biol, 2017 Dec 1. PMID 32550354, Free PMC Article
  2. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
  3. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
  4. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  5. Functional genomic identification of genes required for male gonadal differentiation in Caenorhabditis elegans. Kalis AK, et al. Genetics, 2010 Jun. PMID 20308279, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage stimulating factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage stimulating factor complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cleavage stimulation factor 50 kDa subunit
NP_495822.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8600449..8602440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063421.7 → NP_495822.1  Cleavage stimulation factor 50 kDa subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495822.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19864
    Conserved Domains (3) summary
    cd00200
    Location:101 → 421
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:114 → 168
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:3 → 60
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerization domain
Nucleotide Protein
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