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eif-3.G Eukaryotic translation initiation factor 3 subunit G [ Caenorhabditis elegans ]

Gene ID: 174346, updated on 5-May-2024

Summary

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Gene symbol
eif-3.G
Gene description
Eukaryotic translation initiation factor 3 subunit G
Primary source
WormBase:WBGene00001230
Locus tag
CELE_F22B5.2
See related
AllianceGenome:WB:WBGene00001230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in formation of cytoplasmic translation initiation complex. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and eukaryotic translation initiation factor 3 complex. Is expressed in germ line. Orthologous to human EIF3G (eukaryotic translation initiation factor 3 subunit G). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (8442767..8444175)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ACid Phosphatase family Neighboring gene LIPaSe related Neighboring gene ADP-ribosylation factor-like protein 2 Neighboring gene Cuticlin-3 Neighboring gene Mitochondrial cytochrome c oxidase subunit VIa Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity. Blazie SM, et al. Elife, 2021 Jul 29. PMID 34323215, Free PMC Article
  2. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Kamath RS, et al. Nature, 2003 Jan 16. PMID 12529635
  3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.
    Title: Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 3 subunit G
NP_001263666.1
  • Confirmed by transcript evidence
NP_495778.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8442767..8444175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276737.3 → NP_001263666.1  Eukaryotic translation initiation factor 3 subunit G [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263666.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    K8ESE1, Q19706
    Conserved Domains (3) summary
    COG0724
    Location:176 → 260
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12933
    Location:33 → 143
    eIF3G; eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
    cd12408
    Location:183 → 259
    RRM_eIF3G_like; RNA recognition motif in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins

  2. NM_063377.5 → NP_495778.1  Eukaryotic translation initiation factor 3 subunit G [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495778.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19706
    Conserved Domains (3) summary
    COG0724
    Location:170 → 254
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12933
    Location:27 → 137
    eIF3G; eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
    cd12408
    Location:177 → 253
    RRM_eIF3G_like; RNA recognition motif in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19706.2

Gene LinkOut

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