U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dbt-1 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 174279, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
dbt-1
Gene description
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Primary source
WormBase:WBGene00014054
Locus tag
CELE_ZK669.4
See related
AllianceGenome:WB:WBGene00014054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetyltransferase activity and lipoic acid binding activity. Involved in several processes, including positive regulation of fatty acid biosynthetic process; positive regulation of nematode larval development; and positive regulation of oviposition. Located in cilium; cytosol; and neuron projection. Is expressed in several structures, including body wall musculature; hypodermis; and intestine. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DBT (dihydrolipoamide branched chain transacylase E2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dbt-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (7942602..7945206, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Gamma-interferon-inducible lysosomal thiol reductase Neighboring gene GILT-like protein ZK669.3 Neighboring gene GTP-binding protein Rheb;GTP-binding protein Rhes Neighboring gene Ovule protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Newly Identified Nematodes from Mono Lake Exhibit Extreme Arsenic Resistance. Shih PY, et al. Curr Biol, 2019 Oct 7. PMID 31564490
  2. Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism. Zdraljevic S, et al. Elife, 2019 Apr 8. PMID 30958264, Free PMC Article
  3. Developmental Defects of Caenorhabditis elegans Lacking Branched-chain α-Ketoacid Dehydrogenase Are Mainly Caused by Monomethyl Branched-chain Fatty Acid Deficiency. Jia F, et al. J Biol Chem, 2016 Feb 5. PMID 26683372, Free PMC Article
  4. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Watson E, et al. Cell, 2013 Mar 28. PMID 23540702, Free PMC Article
  5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipoic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
NP_495670.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7942602..7945206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063269.7 → NP_495670.1  Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495670.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23571
    Conserved Domains (4) summary
    cd06849
    Location:31 → 104
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    PLN02528
    Location:33 → 448
    PLN02528; 2-oxoisovalerate dehydrogenase E2 component
    pfam00198
    Location:233 → 445
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    pfam02817
    Location:146 → 179
    E3_binding; e3 binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23571.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous