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kat-1 Acetyl-CoA acetyltransferase homolog, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 174161, updated on 4-Jan-2025

Summary

Official Symbol
kat-1
Official Full Name
Acetyl-CoA acetyltransferase homolog, mitochondrial
Primary source
WormBase:WBGene00002183
Locus tag
CELE_T02G5.8
See related
AllianceGenome:WB:WBGene00002183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetyl-CoA C-acetyltransferase activity. Located in mitochondrion. Is expressed in body wall musculature; gonad; intestine; pharynx; and tail. Used to study obesity. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See kat-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (7073814..7075511)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MutS protein homolog him-14 Neighboring gene Nanos-type domain-containing protein Neighboring gene Lysine--tRNA ligase Neighboring gene Acetyl-CoA C-acetyltransferase Neighboring gene pseudo

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in mitochondrion  
located_in mitochondrion PubMed 
located_in mitochondrion  

General protein information

Preferred Names
Acetyl-CoA acetyltransferase homolog, mitochondrial
NP_495455.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7073814..7075511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063054.8NP_495455.2  Acetyl-CoA acetyltransferase homolog, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495455.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22100
    Conserved Domains (2) summary
    PLN02644
    Location:26407
    PLN02644; acetyl-CoA C-acetyltransferase
    cd00751
    Location:25406
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
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