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Mmp8 matrix metallopeptidase 8 [ Mus musculus (house mouse) ]

Gene ID: 17394, updated on 21-Apr-2024

Summary

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Official Symbol
Mmp8provided by MGI
Official Full Name
matrix metallopeptidase 8provided by MGI
Primary source
MGI:MGI:1202395
See related
Ensembl:ENSMUSG00000005800 AllianceGenome:MGI:1202395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
Expression
Biased expression in liver E18 (RPKM 19.0) and liver E14.5 (RPKM 0.8) See more
Orthologs
human all
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Genomic context

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Location:
9 A1; 9 2.46 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7558430..7568487)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7558429..7568486)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 1a (interstitial collagenase) Neighboring gene STARR-seq mESC enhancer starr_23214 Neighboring gene matrix metallopeptidase 10 Neighboring gene predicted gene, 31751 Neighboring gene matrix metallopeptidase 27 Neighboring gene STARR-seq mESC enhancer starr_23215 Neighboring gene STARR-seq mESC enhancer starr_23216 Neighboring gene matrix metallopeptidase 20 (enamelysin) Neighboring gene STARR-seq mESC enhancer starr_23217 Neighboring gene expressed sequence AV064505

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lab-Attenuated Rabies Virus Facilitates Opening of the Blood-Brain Barrier by Inducing Matrix Metallopeptidase 8. Fang A, et al. J Virol, 2022 Sep 14. PMID 36005758, Free PMC Article
  2. Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. Daly MC, et al. FASEB J, 2016 Oct. PMID 27435263, Free PMC Article
  3. MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. Bian F, et al. J Cell Physiol, 2016 Nov. PMID 26923552, Free PMC Article
  4. A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization. Wen G, et al. J Biol Chem, 2015 Jul 31. PMID 26092731, Free PMC Article
  5. Matrix Metalloproteinase-8 is a Novel Pathogenetic Factor in Focal Cerebral Ischemia. Han JE, et al. Mol Neurobiol, 2016 Jan. PMID 25421209

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circulating myeloid-derived MMP8 in stress susceptibility and depression.
    Title: Circulating myeloid-derived MMP8 in stress susceptibility and depression.
  2. Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
    Title: Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
  3. Lab-Attenuated Rabies Virus Facilitates Opening of the Blood-Brain Barrier by Inducing Matrix Metallopeptidase 8.
    Title: Lab-Attenuated Rabies Virus Facilitates Opening of the Blood-Brain Barrier by Inducing Matrix Metallopeptidase 8.
  4. A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.
    Title: A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.
  5. NPY promotes macrophage migration by upregulating matrix metalloproteinase-8 expression.
    Title: NPY promotes macrophage migration by upregulating matrix metalloproteinase-8 expression.
  6. Endogenous Collagenases Regulate Osteoclast Fusion.
    Title: Endogenous Collagenases Regulate Osteoclast Fusion.
  7. Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response.
    Title: Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response.
  8. Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia.
    Title: Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia.
  9. Taken together, our data manifested that KCNQ1OT1 possibly acts as a facilitator in cerebral I/R injury through modulating miR-9/MMP8 axis as a ceRNA.
    Title: LncRNA KCNQ1OT1 contributes to oxygen-glucose-deprivation/reoxygenation-induced injury via sponging miR-9 in cultured neurons to regulate MMP8.
  10. Suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8.
    Title: Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables tumor necrosis factor binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of positive regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neutrophil collagenase
Names
collagenase-2
matrix metalloproteinase-8
NP_032637.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008611.4 → NP_032637.3  neutrophil collagenase preproprotein

    See identical proteins and their annotated locations for NP_032637.3

    Status: REVIEWED

    Source sequence(s)
    AK137468, BY204369, BY548872
    Consensus CDS
    CCDS22808.1
    UniProtKB/Swiss-Prot
    O70138, O88733, Q6GTR5
    UniProtKB/TrEMBL
    Q3TAV4, Q3TCE6, Q3U1P0, Q8C209
    Related
    ENSMUSP00000018765.3, ENSMUST00000018765.4
    Conserved Domains (4) summary
    cd00094
    Location:276 → 464
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:107 → 262
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:107 → 262
    Peptidase_M10; Matrixin
    pfam01471
    Location:31 → 86
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7558430..7568487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70138.2 GenPept UniProtKB/Swiss-Prot:O70138

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