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mog-5 putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 [ Caenorhabditis elegans ]

Gene ID: 173920, updated on 25-Apr-2024

Summary

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Gene symbol
mog-5
Gene description
putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5
Primary source
WormBase:WBGene00003393
Locus tag
CELE_EEED8.5
See related
AllianceGenome:WB:WBGene00003393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Involved in several processes, including embryonic body morphogenesis; feminization of hermaphroditic germ-line; and germ cell development. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX8 (DEAH-box helicase 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (5399538..5405810)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase pink-1, mitochondrial Neighboring gene Putative RNA-binding protein EEED8.10 Neighboring gene C-type lectin domain-containing protein 141 Neighboring gene Putative RNA-binding protein EEED8.12 Neighboring gene Putative RNA-binding protein EEED8.4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans DDX-23, a homolog of yeast splicing factor PRP28, is required for the sperm-oocyte switch and differentiation of various cell types. Konishi T, et al. Dev Dyn, 2008 Sep. PMID 18729217
  2. The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22. Puoti A, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737793, Free PMC Article
  3. RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Seo M, et al. Proc Natl Acad Sci U S A, 2015 Aug 4. PMID 26195740, Free PMC Article
  4. Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans. Doherty MF, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948787, Free PMC Article
  5. The MEP-1 zinc-finger protein acts with MOG DEAH box proteins to control gene expression via the fem-3 3' untranslated region in Caenorhabditis elegans. Belfiore M, et al. RNA, 2002 Jun. PMID 12088146, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in feminization of hermaphroditic germ-line IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5
NP_495019.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5399538..5405810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062618.7 → NP_495019.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495019.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09530
    Conserved Domains (6) summary
    smart00490
    Location:766 → 870
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:534 → 721
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:939 → 1021
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:557 → 695
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd05684
    Location:234 → 311
    S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...
    pfam07717
    Location:1055 → 1154
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09530.1

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