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rpn-5 PCI domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173807, updated on 5-May-2024

Summary

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Gene symbol
rpn-5
Gene description
PCI domain-containing protein
Primary source
WormBase:WBGene00004461
Locus tag
CELE_F10G7.8
See related
AllianceGenome:WB:WBGene00004461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be part of nuclear proteasome complex and proteasome regulatory particle, lid subcomplex. Predicted to be active in cytoplasm. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; rectum; and reproductive system. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rpn-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (4696421..4698294, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene MFS domain-containing protein Neighboring gene Sister chromatid cohesion protein 1 Neighboring gene putative histone chaperone asf-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Lehrbach NJ, et al. Elife, 2019 Apr 11. PMID 30973820, Free PMC Article
  2. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Kahn NW, et al. Biochem J, 2008 Jan 1. PMID 17714076
  3. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Ghazi A, et al. Proc Natl Acad Sci U S A, 2007 Apr 3. PMID 17392428, Free PMC Article
  4. Proteasome activation delays aging in vitro and in vivo. Chondrogianni N, et al. Free Radic Biol Med, 2014 Jun. PMID 24681338
  5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PCI domain-containing protein
NP_494835.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4696421..4698294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062434.6 → NP_494835.1  PCI domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494835.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19324
    Conserved Domains (1) summary
    COG5071
    Location:38 → 480
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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