mog-2 putative U2 small nuclear ribonucleoprotein A' [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: mog-2
Gene description: putative U2 small nuclear ribonucleoprotein A'
Primary source: WormBase:WBGene00003390
Locus tag: CELE_H20J04.8
See related: AllianceGenome:WB:WBGene00003390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables U2 snRNA binding activity. Involved in feminization of hermaphroditic germ-line; germline cell cycle switching, mitotic to meiotic cell cycle; and mRNA 3'-splice site recognition. Located in nucleoplasm. Part of U2 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 2

Sequence:: Chromosome: II; NC_003280.10 (4324361..4326042)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MOG-2 is expressed in most nuclei of somatic and germ cells. In addition to its role in sex determination, mog-2 is required for meiosis. Moreover, MOG-2 binds to U2B''/RNP-3 in the absence of RNA.
Title: Role of the C. elegans U2 snRNP protein MOG-2 in sex determination, meiosis, and splice site selection.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H20J04.b (e-PCR)
- UniSTS:322581

H20J04.c (e-PCR)
- UniSTS:323565

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U2 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U2 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U2 snRNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in feminization of hermaphroditic germ-line	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA 3'-splice site recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U2 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U2 snRNP	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative U2 small nuclear ribonucleoprotein A'

NP_494763.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4324361..4326042

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062362.6 → NP_494763.1 putative U2 small nuclear ribonucleoprotein A' [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494763.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E0AFQ0, Q9BLB6

Conserved Domains (4) summary

pfam14580
Location:1 → 172

LRR_9; Leucine-rich repeat

sd00031
Location:21 → 36

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:115 → 141

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:65 → 108

LRR_4; Leucine Rich repeats (2 copies)