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Mki67 antigen identified by monoclonal antibody Ki 67 [ Mus musculus (house mouse) ]

Gene ID: 17345, updated on 14-May-2024

Summary

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Official Symbol
Mki67provided by MGI
Official Full Name
antigen identified by monoclonal antibody Ki 67provided by MGI
Primary source
MGI:MGI:106035
See related
Ensembl:ENSMUSG00000031004 AllianceGenome:MGI:106035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ki67; Ki-67; D630048A14Rik
Summary
Predicted to enable protein C-terminus binding activity. Involved in regulation of chromatin organization. Acts upstream of or within cholangiocyte proliferation; hepatocyte proliferation; and meiotic cell cycle. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 21.8), liver E14.5 (RPKM 14.9) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 81.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (135291513..135318286, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (135689784..135716450, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type E Neighboring gene microRNA 1962 Neighboring gene STARR-seq mESC enhancer starr_20364 Neighboring gene STARR-seq mESC enhancer starr_20365 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142829243-142829444 Neighboring gene RIKEN cDNA 5830432E09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142844161-142844270 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142849909-142850110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142860527-142860728 Neighboring gene STARR-positive B cell enhancer ABC_E1096 Neighboring gene STARR-positive B cell enhancer ABC_E1745 Neighboring gene STARR-positive B cell enhancer ABC_E8218 Neighboring gene predicted gene, 36431 Neighboring gene RIKEN cDNA 6330420H09 gene Neighboring gene predicted gene 45241

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study. Vuhahula EA, et al. BMJ Open Ophthalmol, 2022 Sep. PMID 36161862, Free PMC Article
  2. Towards a unified model of naive T cell dynamics across the lifespan. Rane S, et al. Elife, 2022 Jun 9. PMID 35678373, Free PMC Article
  3. Changes in Ki-67 in Residual Tumor and Outcome of Primary Inflammatory Breast Cancer Treated With Trimodality Therapy. Song Z, et al. Clin Breast Cancer, 2022 Jul. PMID 35248490
  4. Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is ≥10%? Merola E, et al. Oncologist, 2021 Apr. PMID 33301235, Free PMC Article
  5. Monitoring tumor proliferative response to radiotherapy using (18)F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67. Fatema CN, et al. Ann Nucl Med, 2013 May. PMID 23417197

See all (2339) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors.
    Title: Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors.
  2. Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study.
    Title: Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study.
  3. Changes in Ki-67 in Residual Tumor and Outcome of Primary Inflammatory Breast Cancer Treated With Trimodality Therapy.
    Title: Changes in Ki-67 in Residual Tumor and Outcome of Primary Inflammatory Breast Cancer Treated With Trimodality Therapy.
  4. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis.
    Title: Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis.
  5. Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
    Title: Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
  6. Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice.
    Title: Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice.
  7. Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis.
    Title: Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis.
  8. Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is >/=10%?
    Title: Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is ≥10%?
  9. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
    Title: S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
  10. To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell Analysis.
    Title: To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell Analysis.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cholangiocyte proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within epithelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hepatocyte proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
proliferation marker protein Ki-67
Names
antigen KI-67 homolog
antigen Ki67 homolog
antigen identified by monoclonal antibody Ki-67 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081117.2 → NP_001074586.2  proliferation marker protein Ki-67

    Status: VALIDATED

    Source sequence(s)
    AC123047, AK052772, AK143677, BC053453
    Consensus CDS
    CCDS52421.1
    UniProtKB/Swiss-Prot
    E9PVX6, Q61769, Q7TSF6
    Related
    ENSMUSP00000033310.8, ENSMUST00000033310.9
    Conserved Domains (4) summary
    COG1716
    Location:11 → 92
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:7 → 101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:1109 → 1216
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:463 → 529
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    135291513..135318286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507413.5 → XP_006507476.1  proliferation marker protein Ki-67 isoform X2

    Conserved Domains (3) summary
    cd00060
    Location:7 → 101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:1854 → 1964
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:143 → 184
    PP1_bind; Protein phosphatase 1 binding

  2. XM_036152742.1 → XP_036008635.1  proliferation marker protein Ki-67 isoform X1

    Conserved Domains (2) summary
    pfam08065
    Location:2030 → 2140
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:318 → 360
    PP1_bind; Protein phosphatase 1 binding
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PVX6.1 GenPept UniProtKB/Swiss-Prot:E9PVX6

Gene LinkOut

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