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etr-1 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173401, updated on 5-May-2024

Summary

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Gene symbol
etr-1
Gene description
RRM domain-containing protein
Primary source
WormBase:WBGene00001340
Locus tag
CELE_T01D1.2
See related
AllianceGenome:WB:WBGene00001340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Involved in determination of adult lifespan. Located in nucleus. Is expressed in body wall musculature; copulatory spicule; germ line; muscle cell; and somatic gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to several human genes including CELF1 (CUGBP Elav-like family member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (162423..170631)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Predicted RNA-Binding Protein ETR-1/CELF1 Acts in Muscles To Regulate Neuroblast Migration in Caenorhabditis elegans. Ochs ME, et al. G3 (Bethesda), 2020 Jul 7. PMID 32398235, Free PMC Article
  2. ETR-1, a homologue of a protein linked to myotonic dystrophy, is essential for muscle development in Caenorhabditis elegans. Milne CA, et al. Curr Biol, 1999 Nov 4. PMID 10556089
  3. Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses. Boateng R, et al. Dev Biol, 2017 Sep 1. PMID 28648844, Free PMC Article
  4. Growth-dependent effect of muscleblind knockdown on Caenorhabditis elegans. Wang LC, et al. Biochem Biophys Res Commun, 2008 Feb 15. PMID 18082131
  5. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans. Ohno G, et al. PLoS Genet, 2012. PMID 23071450, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this data identifies a novel role for ETR-1 in hermaphrodite gametogenesis and in the process of engulfment of germline apoptotic cell corpses.
    Title: Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001367867.1
  • Confirmed by transcript evidence
NP_001367869.1
  • Confirmed by transcript evidence
NP_001367870.1
  • Confirmed by transcript evidence
NP_001367871.1
  • Confirmed by transcript evidence
NP_001368521.1
  • Confirmed by transcript evidence
NP_001368522.1
  • Confirmed by transcript evidence
NP_001368523.1
  • Confirmed by transcript evidence
NP_001368524.1
  • Confirmed by transcript evidence
NP_001368525.1
  • Confirmed by transcript evidence
NP_001368526.1
  • Confirmed by transcript evidence
NP_001368527.1
  • Confirmed by transcript evidence
NP_001368528.1
  • Confirmed by transcript evidence
NP_001368529.1
  • Confirmed by transcript evidence
NP_001368530.1
  • Confirmed by transcript evidence
NP_001368531.1
  • Confirmed by transcript evidence
NP_001368532.1
  • Confirmed by transcript evidence
NP_001368533.1
  • Confirmed by transcript evidence
NP_001370740.1
  • Confirmed by transcript evidence
NP_001379970.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    162423..170631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381293.1 → NP_001367870.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS1
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 580
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:503 → 575
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  2. NM_001381292.3 → NP_001367871.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS0
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 582
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:505 → 577
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  3. NM_001392986.1 → NP_001379970.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7KQE9
    Conserved Domains (3) summary
    cd12362
    Location:430 → 502
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  4. NM_001381290.3 → NP_001367867.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF03
    Conserved Domains (3) summary
    cd12362
    Location:501 → 573
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  5. NM_001381291.1 → NP_001368521.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUP0
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 583
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:506 → 578
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:141 → 221
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  6. NM_001383771.1 → NP_001370740.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS3
    Conserved Domains (4) summary
    TIGR01628
    Location:57 → 529
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:452 → 524
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12631
    Location:54 → 135
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:141 → 209
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_001381296.1 → NP_001368522.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX05
    Conserved Domains (3) summary
    TIGR01661
    Location:285 → 458
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:381 → 453
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12636
    Location:17 → 97
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  8. NM_001381297.1 → NP_001368523.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARP1
    Conserved Domains (3) summary
    TIGR01661
    Location:285 → 456
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:379 → 451
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12636
    Location:17 → 97
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  9. NM_001381298.1 → NP_001368524.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU13
    Conserved Domains (2) summary
    cd12362
    Location:306 → 378
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cd12636
    Location:17 → 97
    RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

  10. NM_001381299.1 → NP_001368525.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR37
    Conserved Domains (3) summary
    TIGR01661
    Location:243 → 416
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:339 → 411
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cl17169
    Location:39 → 55
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. NM_001381300.1 → NP_001368526.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUP5
    Conserved Domains (3) summary
    TIGR01661
    Location:243 → 414
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:337 → 409
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cl17169
    Location:39 → 55
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. NM_001381301.1 → NP_001368527.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX10
    Conserved Domains (2) summary
    cd12362
    Location:264 → 336
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
    cl17169
    Location:39 → 55
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. NM_001381302.1 → NP_001367869.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYR9
    Conserved Domains (1) summary
    cd12362
    Location:269 → 341
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  14. NM_001381303.1 → NP_001368528.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARP5
    Conserved Domains (2) summary
    TIGR01661
    Location:177 → 350
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:273 → 345
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  15. NM_001381304.1 → NP_001368529.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU17
    Conserved Domains (2) summary
    TIGR01661
    Location:177 → 348
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:271 → 343
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  16. NM_001381305.1 → NP_001368530.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR42
    Conserved Domains (1) summary
    cd12362
    Location:198 → 270
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  17. NM_001381306.1 → NP_001368531.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUQ1
    Conserved Domains (2) summary
    TIGR01661
    Location:101 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:197 → 269
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  18. NM_001381307.1 → NP_001368532.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX15
    Conserved Domains (2) summary
    TIGR01661
    Location:101 → 272
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12362
    Location:195 → 267
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

  19. NM_001381308.1 → NP_001368533.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARQ0
    Conserved Domains (1) summary
    cd12362
    Location:122 → 194
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

RNA

  1. NR_132573.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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