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hrpr-1 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173086, updated on 5-May-2024

Summary

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Gene symbol
hrpr-1
Gene description
RRM domain-containing protein
Primary source
WormBase:WBGene00002000
Locus tag
CELE_F58D5.1
See related
AllianceGenome:WB:WBGene00002000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Located in nucleus. Is expressed widely. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R) and SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (12060271..12064897, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cystatin domain-containing protein Neighboring gene Kinase suppressor of Ras B Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene MARVEL domain-containing protein;Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HRP-2, the Caenorhabditis elegans homolog of mammalian heterogeneous nuclear ribonucleoproteins Q and R, is an alternative splicing factor that binds to UCUAUC splicing regulatory elements. Kabat JL, et al. J Biol Chem, 2009 Oct 16. PMID 19706616, Free PMC Article
  2. HRP-2, a heterogeneous nuclear ribonucleoprotein, is essential for embryogenesis and oogenesis in Caenorhabditis elegans. Kinnaird JH, et al. Exp Cell Res, 2004 Aug 15. PMID 15265690
  3. ALG-1 Influences Accurate mRNA Splicing Patterns in the Caenorhabditis elegans Intestine and Body Muscle Tissues by Modulating Splicing Factor Activities. Kotagama K, et al. Genetics, 2019 Jul. PMID 31073019, Free PMC Article
  4. Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. Zheleva A, et al. PLoS Genet, 2019 Sep. PMID 31525188, Free PMC Article
  5. The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Akay A, et al. Dev Cell, 2017 Aug 7. PMID 28787591, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HRP-2 is a protein responsible for regulating alternative splicing through binding interactions with the UCUAUC sequence
    Title: HRP-2, the Caenorhabditis elegans homolog of mammalian heterogeneous nuclear ribonucleoproteins Q and R, is an alternative splicing factor that binds to UCUAUC splicing regulatory elements.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001129778.1
  • Confirmed by transcript evidence
NP_493049.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12060271..12064897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060648.6 → NP_493049.2  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493049.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NLD1
    Conserved Domains (3) summary
    cd12249
    Location:199 → 277
    RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    cd12250
    Location:280 → 362
    RRM2_hnRNPR_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    cd12251
    Location:376 → 445
    RRM3_hnRNPR_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins

  2. NM_001136306.3 → NP_001129778.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3KYC2
Nucleotide Protein
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