timm-23 Mitochondrial import inner membrane translocase subunit TIM23 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: timm-23
Gene description: Mitochondrial import inner membrane translocase subunit TIM23
Primary source: WormBase:WBGene00008857
Locus tag: CELE_F15D3.7
See related: AllianceGenome:WB:WBGene00008857
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mitochondrion targeting sequence binding activity and protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Predicted to be integral component of mitochondrial inner membrane. Is expressed in pharynx. Orthologous to several human genes including TIMM23 (translocase of inner mitochondrial membrane 23). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (11578641..11579612)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F15D3.7 (e-PCR)
- UniSTS:309775

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables mitochondrion targeting sequence binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mitochondrial import inner membrane translocase subunit TIM23

NP_492953.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

11578641..11579612

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060552.7 → NP_492953.1 Mitochondrial import inner membrane translocase subunit TIM23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492953.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XVQ2

Conserved Domains (1) summary

pfam02466
Location:109 → 226

Tim17; Tim17/Tim22/Tim23/Pmp24 family