rpn-10 26S proteasome non-ATPase regulatory subunit 4 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rpn-10
Gene description: 26S proteasome non-ATPase regulatory subunit 4
Primary source: WormBase:WBGene00004466
Locus tag: CELE_B0205.3
See related: AllianceGenome:WB:WBGene00004466
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in spermatogenesis and ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including excretory cell; gonad; intestine; pharynx; and vulva. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rpn-10 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (10730712..10732424, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant.
Title: A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant.
These results show that the RPN-10-mediated ubiquitin pathway is indispensable for control of the TRA-2-mediated sex-determining pathway.
Title: Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0205.3 (e-PCR)
- UniSTS:308825

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 4

NP_492809.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10730712..10732424 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060408.5 → NP_492809.1 26S proteasome non-ATPase regulatory subunit 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492809.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61742

Conserved Domains (1) summary

cl00057
Location:1 → 189

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...