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pab-1 Polyadenylate-binding protein [ Caenorhabditis elegans ]

Gene ID: 172920, updated on 4-Jan-2025

Summary

Official Symbol
pab-1
Official Full Name
Polyadenylate-binding protein
Primary source
WormBase:WBGene00003902
Locus tag
CELE_Y106G6H.2
See related
AllianceGenome:WB:WBGene00003902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables mRNA binding activity. Involved in several processes, including establishment of mitotic spindle localization; positive regulation of vulval development; and regulation of cell cycle process. Located in P granule and P-body. Is expressed in intestine and neurons. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1); PABPC1L (poly(A) binding protein cytoplasmic 1 like); and PABPC3 (poly(A) binding protein cytoplasmic 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See pab-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (10432861..10435238, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Saposin B-type domain-containing protein Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL30 Neighboring gene MADF domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding  
enables mRNA 3'-UTR binding  
enables mRNA binding PubMed 
enables nucleic acid binding  
enables poly(A) binding  
enables poly(U) RNA binding  
enables protein binding PubMed 
Component Evidence Code Pubs
located_in P granule PubMed 
located_in P-body PubMed 
located_in cytoplasm PubMed 
located_in cytoplasm  
is_active_in cytoplasmic stress granule  
is_active_in cytosol  
is_active_in nucleus  
part_of ribonucleoprotein complex  

General protein information

Preferred Names
Polyadenylate-binding protein
NP_001369814.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10432861..10435238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383718.2NP_001369814.1  Polyadenylate-binding protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17350, Q9U302
    Conserved Domains (1) summary
    TIGR01628
    Location:32640
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
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