cel-1 mRNA guanylyltransferase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cel-1
Gene description: mRNA guanylyltransferase
Primary source: WormBase:WBGene00000466
Locus tag: CELE_C03D6.3
See related: AllianceGenome:WB:WBGene00000466
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables polynucleotide 5'-phosphatase activity. Involved in polynucleotide 5' dephosphorylation and positive regulation of gene expression. Located in nucleus. Is expressed in hypodermis; intestine; nervous system; pharynx; and tail. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (9665251..9668650)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CEL-1 and capping are essential for gene expression in metazoans
Title: The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization.
mRNA capping enzyme is required for Caenorhabditis elegans viability
Title: mRNA capping enzyme requirement for Caenorhabditis elegans viability.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C03D6.4 (e-PCR)
- UniSTS:306039

C03D6.3 (e-PCR)
- UniSTS:308907

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-triphosphate monophosphatase activity	IEA Inferred from Electronic Annotation more info
enables mRNA guanylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA guanylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables polynucleotide 5'-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables polynucleotide 5'-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in 7-methylguanosine mRNA capping	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in metabolic process	IEA Inferred from Electronic Annotation more info
involved_in polynucleotide 5' dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA guanylyltransferase

NP_001020979.1

Confirmed by transcript evidence

NP_001020980.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9665251..9668650

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025808.6 → NP_001020979.1 mRNA guanylyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020979.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02558, Q17607

Conserved Domains (3) summary

cd17664
Location:18 → 185

Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme

pfam01331
Location:289 → 479

mRNA_cap_enzyme; mRNA capping enzyme, catalytic domain

pfam03919
Location:484 → 583

mRNA_cap_C; mRNA capping enzyme, C-terminal domain
NM_001025809.3 → NP_001020980.1 mRNA guanylyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020980.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6A3Q2

Conserved Domains (3) summary

pfam01331
Location:277 → 467

mRNA_cap_enzyme; mRNA capping enzyme, catalytic domain

pfam03919
Location:472 → 571

mRNA_cap_C; mRNA capping enzyme, C-terminal domain

cl21483
Location:103 → 159

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...