Rab8a RAB8A, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab8aprovided by MGI
Official Full Name: RAB8A, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:96960
See related: Ensembl:ENSMUSG00000003037 AllianceGenome:MGI:96960
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mel
Summary: Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; plasma membrane bounded cell projection organization; and protein transport. Predicted to act upstream of or within autophagy; cell projection organization; and protein transport. Located in several cellular components, including ciliary basal body; ciliary base; and cytoplasmic vesicle. Is expressed in neural retina and photoreceptor layer. Orthologous to human RAB8A (RAB8A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 57.7), duodenum adult (RPKM 54.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72915044..72935210)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (72161200..72181366)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab8A promotes breast cancer progression by increasing surface expression of Tropomyosin-related kinase B.
Title: Rab8A promotes breast cancer progression by increasing surface expression of Tropomyosin-related kinase B.
Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes.
Title: Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes.
These data indicated that RAB8A was required for Golgi distribution, spindle migration, and polar body extrusion via ROCK-mediated actin assembly in mouse oocyte meiosis.
Title: RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis†.
regulates Kir6.2 trafficking in a beta cell line
Title: Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line.
GFP-Rab8a expressed in macrophages is associated with intracellular vesicles and macropinosomes but, in addition, Rab8a is found on sections of the plasma membrane, particularly ruffling edges and dorsal ruffles on the cell surface near adjacent macropinosomes.
Title: Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes.
overexpression of Rab11a and Rab8a increases the number of tunneling nanotubes-connected cells.
Title: Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling.
Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.
Title: Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.
The small GTPase Rab8a regulates lipid uptake and storage in skeletal muscle.
Title: Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors
Title: Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors.
With CRISPR/Cas9-mediated gene editing to stably knock out and recover Rab8a in macrophage cell lines, this study matches Akt signaling profiles with cytokine outputs, confirming that Rab8a is a novel regulator of the Akt/mammalian target of rapamycin (mTOR) pathway downstream of multiple Toll-like Receptors.
Title: Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	TAS Traceable Author Statement more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle fusion to target membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking involved in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport in synapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IMP Inferred from Mutant Phenotype more info	PubMed
colocalizes_with cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-8A

Names: cell line NK14 derived transforming oncogene; oncogene c-mel

NP_075615.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.