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rskn-1 Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase [ Caenorhabditis elegans ]

Gene ID: 172647, updated on 25-Apr-2024

Summary

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Gene symbol
rskn-1
Gene description
Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase
Primary source
WormBase:WBGene00011352
Locus tag
CELE_T01H8.1
See related
AllianceGenome:WB:WBGene00011352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ribosomal protein S6 kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to several human genes including RPS6KA1 (ribosomal protein S6 kinase A1); RPS6KA2 (ribosomal protein S6 kinase A2); and RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (8573852..8580205, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene LSDAT_euk domain-containing protein;Transient receptor potential channel Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-serine ammonia-lyase Neighboring gene Smad protein daf-8 Neighboring gene putative nuclear transport factor 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline. Cha DS, et al. Biochim Biophys Acta, 2012 Oct. PMID 22820175
  2. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Syntichaki P, et al. Nature, 2007 Feb 22. PMID 17277769
  3. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
  4. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
  5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase
NP_001021602.1
  • Confirmed by transcript evidence
NP_001021603.1
  • Confirmed by transcript evidence
NP_001122504.1
  • Confirmed by transcript evidence
NP_001379180.1
  • Confirmed by transcript evidence
NP_492319.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8573852..8580205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059918.4 → NP_492319.2  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492319.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21734, Q58A96, Q7YSN4, Q93972, Q93973
    Conserved Domains (3) summary
    smart00220
    Location:104 → 363
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:108 → 424
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:453 → 748
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  2. NM_001026431.3 → NP_001021602.1  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021602.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21734
    Conserved Domains (3) summary
    smart00220
    Location:65 → 324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:69 → 385
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:414 → 709
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  3. NM_001392686.1 → NP_001379180.1  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd05582
    Location:51 → 367
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:396 → 691
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  4. NM_001129032.5 → NP_001122504.1  Ribosomal protein S6 kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122504.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE78
    Conserved Domains (3) summary
    smart00220
    Location:98 → 357
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:102 → 418
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:447 → 744
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

  5. NM_001026432.5 → NP_001021603.1  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021603.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21734
    Conserved Domains (3) summary
    smart00220
    Location:85 → 344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:89 → 405
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cl21453
    Location:434 → 669
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21734.4

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