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prpf-4 Protein kinase domain-containing protein;Serine/threonine-protein kinase PRP4 homolog [ Caenorhabditis elegans ]

Gene ID: 172443, updated on 25-Apr-2024

Summary

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Gene symbol
prpf-4
Gene description
Protein kinase domain-containing protein;Serine/threonine-protein kinase PRP4 homolog
Primary source
WormBase:WBGene00004186
Locus tag
CELE_F22D6.5
See related
AllianceGenome:WB:WBGene00004186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in nucleus. Orthologous to human PRPF4B (pre-mRNA processing factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (7091309..7094538, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene AN1-type domain-containing protein Neighboring gene Asparagine--tRNA ligase, cytoplasmic Neighboring gene putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Neighboring gene ncRNA Neighboring gene Tudor domain-containing protein Neighboring gene pseudo Neighboring gene 40S ribosomal protein S25

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein. Basson M, et al. Genes Dev, 1996 Aug 1. PMID 8756352
  2. Genetic and molecular analysis of the dpy-14 region in Caenorhabditis elegans. McKim KS, et al. Mol Gen Genet, 1992 May. PMID 1603066
  3. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
  4. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
  5. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein kinase domain-containing protein;Serine/threonine-protein kinase PRP4 homolog
NP_001250391.1
  • Confirmed by transcript evidence
NP_001250392.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7091309..7094538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001263463.4 → NP_001250392.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001250392.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W737
    Conserved Domains (1) summary
    cl21453
    Location:454 → 740
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001263462.5 → NP_001250391.1  Serine/threonine-protein kinase PRP4 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001250391.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19727
    Conserved Domains (1) summary
    cd14135
    Location:454 → 770
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
Nucleotide Protein
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