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ech-1.2 Enoyl-CoA hydratase [ Caenorhabditis elegans ]

Gene ID: 172310, updated on 11-Apr-2024

Summary

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Gene symbol
ech-1.2
Gene description
Enoyl-CoA hydratase
Primary source
WormBase:WBGene00020347
Locus tag
CELE_T08B2.7
See related
AllianceGenome:WB:WBGene00020347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Is expressed in body wall musculature; hypodermis; intestine; nervous system; and tail. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (6206955..6211155, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Very Early Transcript Neighboring gene BAAT_C domain-containing protein Neighboring gene Large ribosomal subunit protein uL23m Neighboring gene phenylalanine--tRNA ligase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition. Zhang J, et al. Exp Cell Res, 2009 Sep 10. PMID 19427851
  2. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
  3. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187
  4. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article
  5. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Enoyl-CoA hydratase
NP_491789.1
  • Confirmed by transcript evidence
NP_491790.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6206955..6211155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059388.8 → NP_491789.1  Enoyl-CoA hydratase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491789.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GYT0
    Conserved Domains (4) summary
    cd06558
    Location:60 → 269
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    TIGR02441
    Location:46 → 780
    fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
    pfam00725
    Location:561 → 656
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:381 → 559
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

  2. NM_059389.6 → NP_491790.1  Enoyl-CoA hydratase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIC3
    Conserved Domains (4) summary
    cd06558
    Location:34 → 243
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    TIGR02441
    Location:20 → 754
    fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
    pfam00725
    Location:535 → 630
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:355 → 533
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Nucleotide Protein
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