Mc3r melanocortin 3 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mc3rprovided by MGI
Official Full Name: melanocortin 3 receptorprovided by MGI
Primary source: MGI:MGI:96929
See related: Ensembl:ENSMUSG00000038537 AllianceGenome:MGI:96929
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MC3-R
Summary: This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis and adaptation to food restriction. Disruption of this gene results in an increased ratio of weight gain to food intake, increased fat mass, and decreased lean mass, without having a large effect on insulin sensitivity or glucose metabolism. [provided by RefSeq, Dec 2012]
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 94.8 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (172090412..172093034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (172248492..172251114)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
Title: Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
Paraventricular Thalamic MC3R Circuits Link Energy Homeostasis with Anxiety-Related Behavior.
Title: Paraventricular Thalamic MC3R Circuits Link Energy Homeostasis with Anxiety-Related Behavior.
Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.
Title: Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.
MC3R links nutritional state to childhood growth and the timing of puberty.
Title: MC3R links nutritional state to childhood growth and the timing of puberty.
Identification of novel GPCR partners of the central melanocortin signaling.
Title: Identification of novel GPCR partners of the central melanocortin signaling.
Whole-brain efferent and afferent connectivity of mouse ventral tegmental area melanocortin-3 receptor neurons.
Title: Whole-brain efferent and afferent connectivity of mouse ventral tegmental area melanocortin-3 receptor neurons.
Mc3R neurons lie within lateral hypothalamic area neurocircuitry that modulates locomotor activity and energy expenditure and contribute to energy balance control.
Title: Lateral Hypothalamic Mc3R-Expressing Neurons Modulate Locomotor Activity, Energy Expenditure, and Adiposity in Male Mice.
important in response of arcuate nucleus neurons to fasting
Title: Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice.
MC3Rs expressed in Nkx2.1(+ve) neurons are sufficient to coordinate hypothalamic response and expression of compulsive behavioral responses involving meal anticipation and consumption of large meals during situations of prolonged negative energy balance.
Title: Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning.
Replacing murine Mc3r with and double-mutant (C17A+G241A) human MC3R showed greater weight and fat mass, increased energy intake and feeding efficiency.
Title: A mouse model for a partially inactive obesity-associated human MC3R variant.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:484941 (e-PCR)
- UniSTS:484941

X74983 (e-PCR)
- UniSTS:159080

Edn3 (e-PCR), detects polymorphism
- UniSTS:142962

Edn3 (e-PCR), detects polymorphism
- UniSTS:142963

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables melanocortin receptor activity	ISO Inferred from Sequence Orthology more info
enables melanocyte-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melanocyte-stimulating hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables melanocyte-stimulating hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homoiothermy	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanocortin receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.