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mcm-4 DNA replication licensing factor mcm-4 [ Caenorhabditis elegans ]

Gene ID: 171793, updated on 25-Apr-2024

Summary

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Gene symbol
mcm-4
Gene description
DNA replication licensing factor mcm-4
Primary source
WormBase:WBGene00003156
Locus tag
CELE_Y39G10AR.14
See related
AllianceGenome:WB:WBGene00003156
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in gonad development; locomotion; and nervous system development. Located in nucleus. Is expressed in several structures, including P lineage cell; P1; Q lineage cell; somatic gonad precursor; and sperm. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (2318291..2321817, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene protein-synthesizing GTPase Neighboring gene Tubulin-specific chaperone A Neighboring gene ncRNA Neighboring gene PEHE domain-containing protein Neighboring gene BLOC-1-related complex subunit 7;Biogenesis of lysosome-related organelles complex 1 subunit 3 Neighboring gene DUF5523 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A dual transcriptional reporter and CDK-activity sensor marks cell cycle entry and progression in C. elegans. van Rijnberk LM, et al. PLoS One, 2017. PMID 28158315, Free PMC Article
  2. C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability. Korzelius J, et al. Dev Biol, 2011 Feb 15. PMID 21146520, Free PMC Article
  3. Connectivity changes in a class of motoneurone during the development of a nematode. White JG, et al. Nature, 1978 Feb 23. PMID 625347
  4. lin-14 regulates the timing of synaptic remodelling in Caenorhabditis elegans. Hallam SJ, et al. Nature, 1998 Sep 3. PMID 9738501
  5. GABA is dispensable for the formation of junctional GABA receptor clusters in Caenorhabditis elegans. Gally C, et al. J Neurosci, 2003 Apr 1. PMID 12684444, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C. elegans mcm-4 has conserved functions in DNA replication and replication checkpoint control but also shows unexpected tissue-specific requirements.
    Title: C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
part_of MCM complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication licensing factor mcm-4
NP_001293322.1
  • Confirmed by transcript evidence
NP_490962.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2318291..2321817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058561.6 → NP_490962.1  DNA replication licensing factor mcm-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490962.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XQ8
    Conserved Domains (2) summary
    pfam14551
    Location:121 → 226
    MCM_N; MCM N-terminal domain
    cl25443
    Location:230 → 730
    MCM_OB; MCM OB domain

  2. NM_001306393.3 → NP_001293322.1  DNA replication licensing factor mcm-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293322.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AL94
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95XQ8.1

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