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Y71G12B.10 hydroxymethylglutaryl-CoA lyase [ Caenorhabditis elegans ]

Gene ID: 171738, updated on 11-Apr-2024

Summary

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Gene symbol
Y71G12B.10
Gene description
hydroxymethylglutaryl-CoA lyase
Primary source
WormBase:WBGene00022150
Locus tag
CELE_Y71G12B.10
See related
AllianceGenome:WB:WBGene00022150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process; leucine catabolic process; and lipid metabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to several human genes including HMGCLL1 (3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (1751481..1754410)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene Mitochondrial-processing peptidase subunit alpha Neighboring gene ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene RNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxo-acid-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ketone body biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA lyase
NP_490889.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1751481..1754410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058488.6 → NP_490889.1  hydroxymethylglutaryl-CoA lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490889.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XN1
    Conserved Domains (1) summary
    cd07938
    Location:21 → 293
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
Nucleotide Protein
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