U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

acs-13 Long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

Gene ID: 171643, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
acs-13
Gene description
Long-chain-fatty-acid--CoA ligase
Primary source
WormBase:WBGene00022037
Locus tag
CELE_Y65B4BL.5
See related
AllianceGenome:WB:WBGene00022037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in body wall musculature; head; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to several human genes including ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (511044..519646, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene P-granule-associated protein deps-1 Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene (Na+)-NQR maturation NqrM Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of CED-3 substrates by a yeast-based screening method. Kim SY, et al. Mol Biotechnol, 2004 May. PMID 15122042
  2. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
  3. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Long-chain-fatty-acid--CoA ligase
NP_001293196.1
  • Confirmed by transcript evidence
NP_001368382.1
  • Confirmed by transcript evidence
NP_490744.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    511044..519646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058343.5 → NP_490744.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N302
    Conserved Domains (1) summary
    cd05927
    Location:140 → 716
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_001306267.3 → NP_001293196.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLI5
    Conserved Domains (1) summary
    cd05927
    Location:147 → 723
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. NM_001379780.1 → NP_001368382.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CK48
    Conserved Domains (1) summary
    cd05927
    Location:97 → 673
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous