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Map3k2 mitogen activated protein kinase kinase kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171492, updated on 13-Apr-2024

Summary

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Official Symbol
Map3k2provided by RGD
Official Full Name
mitogen activated protein kinase kinase kinase 2provided by RGD
Primary source
RGD:620967
See related
Ensembl:ENSRNOG00000014089 AllianceGenome:RGD:620967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mekk2
Summary
Enables MAP kinase kinase kinase activity. Involved in protein phosphorylation. Located in cytosol and nucleus. Orthologous to human MAP3K2 (mitogen-activated protein kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 134.6), Thymus (RPKM 114.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (24081444..24153940)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23807218..23879722)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24961250..25025488)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098222 Neighboring gene uncharacterized LOC134482924 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene bridging integrator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures. Lenz G, et al. J Neurochem, 2001 May. PMID 11359865
  2. Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2. Wang AD, et al. Eur Rev Med Pharmacol Sci, 2021 Jan. PMID 33506923
  3. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA, et al. FEBS Lett, 2000 Jan 21. PMID 10648842
  4. Regulation of cellular functions by the ERK5 signalling pathway. Wang X, et al. Cell Signal, 2006 Jun. PMID 16376520
  5. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. Raviv Z, et al. J Cell Sci, 2004 Apr 1. PMID 15075238

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2.
    Title: Upregulation of miR-335 reduces myocardial injury following myocardial infarction via targeting MAP3K2.
  2. Rap1 and MEKK2 are critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons
    Title: Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.
  3. Unlike ERK5 and MEK5, their upstream activator MEKK2 is localized mainly in the cytosol of resting cells, and translocates into the nucleus upon EGF stimulation
    Title: MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 2
NP_612512.1
XP_038952487.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138503.1 → NP_612512.1  mitogen-activated protein kinase kinase kinase 2

    See identical proteins and their annotated locations for NP_612512.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6J2Q3, F1M9D0
    Related
    ENSRNOP00000057715.2, ENSRNOT00000060996.4
    Conserved Domains (3) summary
    cd06405
    Location:44 → 122
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:356 → 616
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06652
    Location:353 → 616
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    24081444..24153940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096559.2 → XP_038952487.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    Conserved Domains (1) summary
    cd06652
    Location:155 → 418
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
Nucleotide Protein Strain
Heading Accession and Version

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