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il17rd interleukin 17 receptor D [ Danio rerio (zebrafish) ]

Gene ID: 171474, updated on 27-Mar-2024

Summary

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Official Symbol
il17rdprovided by ZNC
Official Full Name
interleukin 17 receptor Dprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020320-5
See related
Ensembl:ENSDARG00000098359 AllianceGenome:ZFIN:ZDB-GENE-020320-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sef; cb208; id:ibd2875; id:ibd5059; zgc:136328
Summary
Predicted to enable interleukin-17 receptor activity. Acts upstream of or within dorsal/ventral pattern formation; negative regulation of MAPK cascade; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural keel; and neural rod. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 18 with or without anosmia. Orthologous to human IL17RD (interleukin 17 receptor D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See il17rd in Genome Data Viewer
Location:
chromosome: 11
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (42641469..42719359)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (42352132..42429269)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Neighboring gene HESX homeobox 1 Neighboring gene si:ch73-106k19.2 Neighboring gene zgc:194981

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sef is synexpressed with FGFs during chick embryogenesis and its expression is differentially regulated by FGFs in the developing limb. Harduf H, et al. Dev Dyn, 2005 Jun. PMID 15844098
  2. Evolution of vertebrate immunity: sequence and functional analysis of the SEFIR domain family member Act1. Ryzhakov G, et al. J Mol Evol, 2011 Jun. PMID 21643828
  3. Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Fürthauer M, et al. Nat Cell Biol, 2002 Feb. PMID 11802165
  4. Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Lee Y, et al. Development, 2005 Dec. PMID 16251209
  5. Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear. Asai Y, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754885, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC136328

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-17 receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
interleukin-17 receptor D
Names
IL-17 receptor D
IL-17RD
similar expression to FGF genes protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328553.2 → NP_001315482.2  interleukin-17 receptor D isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    CU459094, CU459189
    UniProtKB/Swiss-Prot
    Q4VBV6, Q8QHJ6, Q8QHJ9
    UniProtKB/TrEMBL
    A0A0R4INF1, B3DKQ2
    Related
    ENSDARP00000136390.3, ENSDART00000169938.3
    Conserved Domains (3) summary
    pfam08357
    Location:354 → 517
    SEFIR; SEFIR domain
    pfam16742
    Location:46 → 167
    IL17R_D_N; N-terminus of interleukin 17 receptor D
    cl01930
    Location:234 → 279
    DUF2141; Uncharacterized protein conserved in bacteria (DUF2141)

  2. NM_153660.3 → NP_705946.3  interleukin-17 receptor D isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CU459094, CU459189
    UniProtKB/Swiss-Prot
    Q4VBV6, Q8QHJ6, Q8QHJ9
    Related
    ENSDARP00000140479.2, ENSDART00000172641.3
    Conserved Domains (3) summary
    pfam08357
    Location:355 → 518
    SEFIR; SEFIR domain
    pfam16742
    Location:47 → 168
    IL17R_D_N; N-terminus of interleukin 17 receptor D
    cl01930
    Location:235 → 280
    DUF2141; Uncharacterized protein conserved in bacteria (DUF2141)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    42641469..42719359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QHJ9.2 GenPept UniProtKB/Swiss-Prot:Q8QHJ9

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