U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adgrl2 adhesion G protein-coupled receptor L2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171447, updated on 11-Apr-2024

Summary

Official Symbol
Adgrl2provided by RGD
Official Full Name
adhesion G protein-coupled receptor L2provided by RGD
Primary source
RGD:620835
See related
Ensembl:ENSRNOG00000063253 Ensembl:ENSRNOG00000065347 AllianceGenome:RGD:620835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cirl2; Cl2ac; Lphn2; Cirl-2
Summary
Enables PDZ domain binding activity. Involved in brain development. Located in neuron projection. Orthologous to human ADGRL2 (adhesion G protein-coupled receptor L2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 155.2), Liver (RPKM 125.0) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Adgrl2 in Genome Data Viewer
Location:
2q45
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (240356176..240987246, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (237696055..238327141, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (258792838..258997145, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486003 Neighboring gene uncharacterized LOC120101103 Neighboring gene uncharacterized LOC102547720 Neighboring gene uncharacterized LOC134486004 Neighboring gene uncharacterized LOC102547649 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120101101 Neighboring gene uncharacterized LOC134486005 Neighboring gene uncharacterized LOC102547779

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor L2
Names
calcium-independent alpha-latrotoxin receptor 2
calcium-independent alpha-latrotoxin receptor homolog 2
latrophilin-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190475.2NP_001177404.2  adhesion G protein-coupled receptor L2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177404.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081153, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/TrEMBL
    A0A8I6A5I7, A6HWH0, D3ZBE9
    Related
    ENSRNOP00000085707.1, ENSRNOT00000105330.1
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191478
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:850875
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481120
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001302208.1NP_001289137.1  adhesion G protein-coupled receptor L2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001289137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081151, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/TrEMBL
    A6HWG7
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191467
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:850875
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481120
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001302209.1NP_001289138.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001289138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (4) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081150, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/TrEMBL
    A6HWG5
    Related
    ENSRNOP00000084635.1, ENSRNOT00000120239.1
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:850875
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481105
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_001302210.1NP_001289139.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001289139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons and has an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (5) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081148, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/TrEMBL
    A6HWG0
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041452
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:850875
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481105
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. NM_001302211.1NP_001289140.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001289140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (6) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081152, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/TrEMBL
    A0A8I5ZZY9, A6HWG9
    Related
    ENSRNOP00000085342.1, ENSRNOT00000096110.1
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191435
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:850875
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481120
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. NM_001302212.1NP_001289141.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

    See identical proteins and their annotated locations for NP_001289141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (7) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081149, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/TrEMBL
    A6HWG3
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041420
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:850875
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481105
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. NM_134408.3NP_599235.3  adhesion G protein-coupled receptor L2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA899882, AF063102, AF081148, AF081151, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88918, O88919, O88920, O88921, O88922, O88923, Q9Z174
    UniProtKB/TrEMBL
    F1M7T0
    Related
    ENSRNOP00000042136.5, ENSRNOT00000045905.6
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11281487
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:850875
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481129
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    240356176..240987246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281223.1XP_063137293.1  adhesion G protein-coupled receptor L2 isoform X1

  2. XM_063281268.1XP_063137338.1  adhesion G protein-coupled receptor L2 isoform X40

  3. XM_063281246.1XP_063137316.1  adhesion G protein-coupled receptor L2 isoform X20

    UniProtKB/TrEMBL
    A0A8I5ZUN4
  4. XM_063281234.1XP_063137304.1  adhesion G protein-coupled receptor L2 isoform X10

  5. XM_063281264.1XP_063137334.1  adhesion G protein-coupled receptor L2 isoform X37

  6. XM_063281231.1XP_063137301.1  adhesion G protein-coupled receptor L2 isoform X7

  7. XM_063281225.1XP_063137295.1  adhesion G protein-coupled receptor L2 isoform X1

  8. XM_063281245.1XP_063137315.1  adhesion G protein-coupled receptor L2 isoform X20

    UniProtKB/TrEMBL
    A0A8I5ZUN4
  9. XM_063281266.1XP_063137336.1  adhesion G protein-coupled receptor L2 isoform X38

  10. XM_063281239.1XP_063137309.1  adhesion G protein-coupled receptor L2 isoform X16

  11. XM_063281224.1XP_063137294.1  adhesion G protein-coupled receptor L2 isoform X1

  12. XM_063281254.1XP_063137324.1  adhesion G protein-coupled receptor L2 isoform X28

  13. XM_063281250.1XP_063137320.1  adhesion G protein-coupled receptor L2 isoform X24

  14. XM_063281252.1XP_063137322.1  adhesion G protein-coupled receptor L2 isoform X26

  15. XM_063281247.1XP_063137317.1  adhesion G protein-coupled receptor L2 isoform X21

  16. XM_063281253.1XP_063137323.1  adhesion G protein-coupled receptor L2 isoform X27

  17. XM_063281248.1XP_063137318.1  adhesion G protein-coupled receptor L2 isoform X22

  18. XM_063281251.1XP_063137321.1  adhesion G protein-coupled receptor L2 isoform X25

  19. XM_063281240.1XP_063137310.1  adhesion G protein-coupled receptor L2 isoform X17

  20. XM_063281238.1XP_063137308.1  adhesion G protein-coupled receptor L2 isoform X15

  21. XM_063281249.1XP_063137319.1  adhesion G protein-coupled receptor L2 isoform X23

  22. XM_039101650.2XP_038957578.1  adhesion G protein-coupled receptor L2 isoform X20

    UniProtKB/TrEMBL
    A0A8I5ZUN4, A6HWG3
    Related
    ENSRNOP00000077192.1
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:833858
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8311088
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  23. XM_063281265.1XP_063137335.1  adhesion G protein-coupled receptor L2 isoform X38

  24. XM_039101639.2XP_038957567.1  adhesion G protein-coupled receptor L2 isoform X10

    UniProtKB/TrEMBL
    A6HWG5
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871446
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:833858
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8311088
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  25. XM_063281243.1XP_063137313.1  adhesion G protein-coupled receptor L2 isoform X18

  26. XM_063281237.1XP_063137307.1  adhesion G protein-coupled receptor L2 isoform X14

  27. XM_063281229.1XP_063137299.1  adhesion G protein-coupled receptor L2 isoform X6

  28. XM_063281230.1XP_063137300.1  adhesion G protein-coupled receptor L2 isoform X8

  29. XM_063281227.1XP_063137297.1  adhesion G protein-coupled receptor L2 isoform X4

  30. XM_063281244.1XP_063137314.1  adhesion G protein-coupled receptor L2 isoform X19

  31. XM_063281232.1XP_063137302.1  adhesion G protein-coupled receptor L2 isoform X9

  32. XM_039101645.2XP_038957573.1  adhesion G protein-coupled receptor L2 isoform X16

    UniProtKB/TrEMBL
    A6HWG3
    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001416
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:846871
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8441101
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  33. XM_063281263.1XP_063137333.1  adhesion G protein-coupled receptor L2 isoform X37

  34. XM_039101637.2XP_038957565.1  adhesion G protein-coupled receptor L2 isoform X7

    UniProtKB/TrEMBL
    A6HWG5
    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001459
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:846871
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8441101
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  35. XM_063281228.1XP_063137298.1  adhesion G protein-coupled receptor L2 isoform X5

  36. XM_063281235.1XP_063137305.1  adhesion G protein-coupled receptor L2 isoform X12

  37. XM_039101632.2XP_038957560.1  adhesion G protein-coupled receptor L2 isoform X2

    UniProtKB/TrEMBL
    A6HWH0, D3ZBE9
    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11151474
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:846871
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8441116
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  38. XM_063281236.1XP_063137306.1  adhesion G protein-coupled receptor L2 isoform X13

  39. XM_063281261.1XP_063137331.1  adhesion G protein-coupled receptor L2 isoform X35

  40. XM_063281226.1XP_063137296.1  adhesion G protein-coupled receptor L2 isoform X3

  41. XM_063281233.1XP_063137303.1  adhesion G protein-coupled receptor L2 isoform X11

  42. XM_063281259.1XP_063137329.1  adhesion G protein-coupled receptor L2 isoform X33

  43. XM_063281222.1XP_063137292.1  adhesion G protein-coupled receptor L2 isoform X1

  44. XM_063281255.1XP_063137325.1  adhesion G protein-coupled receptor L2 isoform X29

  45. XM_063281257.1XP_063137327.1  adhesion G protein-coupled receptor L2 isoform X31

  46. XM_063281256.1XP_063137326.1  adhesion G protein-coupled receptor L2 isoform X30

  47. XM_063281258.1XP_063137328.1  adhesion G protein-coupled receptor L2 isoform X32

  48. XM_063281262.1XP_063137332.1  adhesion G protein-coupled receptor L2 isoform X36

  49. XM_063281260.1XP_063137330.1  adhesion G protein-coupled receptor L2 isoform X34

  50. XM_063281267.1XP_063137337.1  adhesion G protein-coupled receptor L2 isoform X39