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Ppp3cc protein phosphatase 3 catalytic subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 171378, updated on 5-Mar-2024

Summary

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Official Symbol
Ppp3ccprovided by RGD
Official Full Name
protein phosphatase 3 catalytic subunit gammaprovided by RGD
Primary source
RGD:621616
See related
Ensembl:ENSRNOG00000009745 AllianceGenome:RGD:621616
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in brain development and positive regulation of synaptic vesicle endocytosis. Located in presynapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 130.3), Heart (RPKM 120.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51699586..51771763, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45289917..45362012, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51896427..51968075, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482142 Neighboring gene PDZ and LIM domain 2 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene mitochondrial pyruvate carrier 1-like Neighboring gene solute carrier family 39 member 14 Neighboring gene histone deacetylase 1-like Neighboring gene piwi-like RNA-mediated gene silencing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task. Havekes R, et al. Learn Mem, 2006 Nov-Dec. PMID 17101875, Free PMC Article
  2. Calcineurin is not involved in some mitochondrial enzyme adaptations to endurance exercise training in rat skeletal muscle. Terada S, et al. Eur J Appl Physiol, 2003 Sep. PMID 12856186
  3. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Gerber DJ, et al. Proc Natl Acad Sci U S A, 2003 Jul 22. PMID 12851458, Free PMC Article
  4. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Fiedler B, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12177418, Free PMC Article
  5. Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development. Eastwood SL, et al. Eur J Neurosci, 2005 Dec. PMID 16367768

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNAi-mediated knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in cultured rat hippocampal neurons.
    Title: Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.
  2. Findings show memory formation is accompanied by reduced CaN activity, whereas adapting to changes in a familiar environment is accompanied by restored CaN activity. Reversal training selectively affects hippocampal CA3 and CA1 regions.
    Title: Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task.
  3. PKG I inhibits cardiac myocyte hypertrophy by targeting the calcineurin-NFAT signaling pathway
    Title: Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within penetration of zona pellucida ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcineurin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  
located_in sperm mitochondrial sheath ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Names
protein phosphatase 3, catalytic subunit, gamma isozyme
NP_599194.1
XP_008769035.1
XP_008769036.1
XP_038948901.1
XP_038948902.1
XP_038948903.1
XP_038948904.1
XP_063130022.1
XP_063130023.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134367.1 → NP_599194.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

    See identical proteins and their annotated locations for NP_599194.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079027
    UniProtKB/TrEMBL
    A0A8J8XJJ2, Q6AYJ0
    Related
    ENSRNOP00000095864.1, ENSRNOT00000100817.1
    Conserved Domains (2) summary
    smart00156
    Location:54 → 325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    51699586..51771763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092976.2 → XP_038948904.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6

    UniProtKB/TrEMBL
    A0A8J8XJJ2
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  2. XM_039092973.2 → XP_038948901.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2

    UniProtKB/TrEMBL
    A0A8J8XJJ2
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  3. XM_008770814.4 → XP_008769036.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4

    See identical proteins and their annotated locations for XP_008769036.1

    UniProtKB/TrEMBL
    A0A8J8XJJ2, E2CWF1
    Related
    ENSRNOP00000069433.1
    Conserved Domains (2) summary
    smart00156
    Location:54 → 325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  4. XM_039092974.2 → XP_038948902.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3

    UniProtKB/TrEMBL
    A0A0G2K820, A0A8J8XJJ2
    Related
    ENSRNOP00000074438.2
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  5. XM_008770813.4 → XP_008769035.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_008769035.1

    UniProtKB/TrEMBL
    A0A8J8XJJ2, E2CWF0, F1M7P9
    Related
    ENSRNOP00000075488.2
    Conserved Domains (2) summary
    smart00156
    Location:54 → 325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  6. XM_039092975.2 → XP_038948903.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

    UniProtKB/TrEMBL
    A0A8J8XJJ2
    Conserved Domains (1) summary
    cd07416
    Location:2 → 303
    MPP_PP2B; PP2B, metallophosphatase domain

  7. XM_063273952.1 → XP_063130022.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

  8. XM_063273953.1 → XP_063130023.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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