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Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 171178, updated on 4-Jan-2025

Summary

Official Symbol
Adh7provided by RGD
Official Full Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideprovided by RGD
Primary source
RGD:621638
See related
EnsemblRapid:ENSRNOG00000032959 AllianceGenome:RGD:621638
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including NAD binding activity; alcohol binding activity; and zinc ion binding activity. Involved in ethanol metabolic process and retinol metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 91.3) and Lung (RPKM 19.8) See more
Orthologs
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Genomic context

See Adh7 in Genome Data Viewer
Location:
2q44
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (229422125..229436584)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (226748724..226763183)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243500540..243516865)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485979 Neighboring gene similar to human chromosome 4 open reading frame 17 Neighboring gene methionyl aminopeptidase 2, pseudogene 4 Neighboring gene uncharacterized LOC134485980 Neighboring gene alcohol dehydrogenase 1C (class I), gamma polypeptide Neighboring gene alcohol dehydrogenase 6A (class V)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding PubMed 
enables alcohol dehydrogenase (NAD+) activity  
enables alcohol dehydrogenase (NAD+) activity PubMed 
enables alcohol dehydrogenase (NAD+) activity  
enables alcohol dehydrogenase (NAD+) activity PubMed 
enables aldehyde oxidase activity  
enables all-trans-retinol dehydrogenase (NAD+) activity  
enables all-trans-retinol dehydrogenase (NAD+) activity  
enables all-trans-retinol dehydrogenase (NAD+) activity  
enables all-trans-retinol dehydrogenase (NAD+) activity  
enables ethanol binding PubMed 
enables ethanol binding  
enables identical protein binding PubMed 
enables omega-hydroxydecanoate dehydrogenase activity  
enables oxidoreductase activity  
enables receptor antagonist activity  
enables retinol binding PubMed 
enables retinol binding  
enables zinc ion binding  
enables zinc ion binding PubMed 
enables zinc ion binding  
Process Evidence Code Pubs
involved_in ethanol catabolic process  
acts_upstream_of_or_within ethanol catabolic process  
involved_in ethanol metabolic process PubMed 
involved_in fatty acid omega-oxidation  
involved_in response to bacterium  
involved_in response to ethanol  
involved_in retinoic acid metabolic process  
involved_in retinoic acid metabolic process  
acts_upstream_of_or_within retinoic acid metabolic process  
involved_in retinoid metabolic process  
involved_in retinoid metabolic process PubMed 
involved_in retinol metabolic process  
involved_in retinol metabolic process PubMed 
involved_in retinol metabolic process  
acts_upstream_of_or_within retinol metabolic process  
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
all-trans-retinol dehydrogenase [NAD(+)] ADH7
Names
alcohol dehydrogenase class 4 mu/sigma chain
alcohol dehydrogenase class IV mu/sigma chain
class IV alcohol dehydrogenase, mu or sigma subunit
omega-hydroxydecanoate dehydrogenase ADH7
NP_599156.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134329.2 → NP_599156.2  all-trans-retinol dehydrogenase [NAD(+)] ADH7

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    O55146, P41682
    UniProtKB/TrEMBL
    A6HW25
    Related
    ENSRNOP00000015870.5, ENSRNOT00000015870.6
    Conserved Domains (1) summary
    cd08299
    Location:3 → 374
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    229422125..229436584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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