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P2ry14 purinergic receptor P2Y14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171108, updated on 13-Apr-2024

Summary

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Official Symbol
P2ry14provided by RGD
Official Full Name
purinergic receptor P2Y14provided by RGD
Primary source
RGD:70912
See related
Ensembl:ENSRNOG00000013872 AllianceGenome:RGD:70912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr105
Summary
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Involved in immune response. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human P2RY14 (purinergic receptor P2Y14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 48.6), Spleen (RPKM 23.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See P2ry14 in Genome Data Viewer
Location:
2q26
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145522598..145563074, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143372697..143413213, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149331948..149379336, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene uncharacterized LOC120100831 Neighboring gene G protein-coupled receptor 171 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. P2Y(14) receptor is functionally expressed in satellite glial cells and mediates interleukin-1β and chemokine CCL2 secretion. Lin J, et al. J Cell Physiol, 2019 Nov. PMID 31032956
  2. Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells. Li F, et al. J Ethnopharmacol, 2016 Jun 5. PMID 26976766
  3. UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation. Gao ZG, et al. Biochem Pharmacol, 2010 Mar 15. PMID 19896471, Free PMC Article
  4. The P2Y14 receptor activity in glioma C6 cells. Krzemiński P, et al. Eur J Pharmacol, 2008 Oct 10. PMID 18638471
  5. Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s). Kinoshita M, et al. Cell Mol Neurobiol, 2013 Jan. PMID 22872320

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our findings directly proved the functional presence of P2Y14 receptor in satellite glial cells. It was also verified that P2Y14 receptor activation was involved in activating satellite glial cells
    Title: P2Y(14) receptor is functionally expressed in satellite glial cells and mediates interleukin-1β and chemokine CCL2 secretion.
  2. Geniposide exerted anti-inflammatory effects by interfering with the expression of P2Y14 receptor, which subsequently inhibits the downstream ERK1/2 signaling pathways and the release of the pro-inflammatory cytokines IL-8, MCP-1, IL-1beta.
    Title: Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells.
  3. When Gi-coupled signaling is removed from astrocyte P2Y14 receptors, the cells start to release TNF-alpha, boosting MMP-9 secretion.
    Title: Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s).
  4. Mast cells express an endogenous P2Y(14) receptor, which mediates G(i)-dependent degranulation and is therefore a potential novel therapeutic target for allergic conditions.
    Title: UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation.
  5. These results demonstrate a novel function of the P2Y14 receptor in the rodent stomach and an ability of UDP-glucose to delay gastric emptying without involving the P2Y14 receptor.
    Title: UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms.
  6. we demonstrated the presence and the activity of the P2Y14 receptor in glioma C6 cells
    Title: The P2Y14 receptor activity in glioma C6 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC93098

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P2Y purinoceptor 14
Names
G protein-coupled receptor 105
G protein-coupled receptor VTR 15-20
P2Y14
UDP-glucose receptor
VTR 15-20
purinergic receptor P2Y, G-protein coupled, 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133577.2 → NP_598261.2  P2Y purinoceptor 14

    Status: VALIDATED

    Source sequence(s)
    FM071543, JAXUCZ010000002
    UniProtKB/Swiss-Prot
    O35881
    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Related
    ENSRNOP00000088251.1, ENSRNOT00000090538.2
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    145522598..145563074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101620.2 → XP_038957548.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/Swiss-Prot
    O35881
    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_039101618.2 → XP_038957546.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/Swiss-Prot
    O35881
    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Related
    ENSRNOP00000073889.1
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_063281219.1 → XP_063137289.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4

  4. XM_039101621.2 → XP_038957549.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/Swiss-Prot
    O35881
    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_017590600.3 → XP_017446089.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/Swiss-Prot
    O35881
    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_017590599.3 → XP_017446088.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/Swiss-Prot
    O35881
    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Related
    ENSRNOP00000093144.1
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. XM_063281221.1 → XP_063137291.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4

  8. XM_039101622.2 → XP_038957550.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/Swiss-Prot
    O35881
    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Conserved Domains (2) summary
    cd14964
    Location:23 → 50
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  9. XM_063281220.1 → XP_063137290.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N8, A0A9K3Y832, Q5XIX4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35881.1 GenPept UniProtKB/Swiss-Prot:O35881

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