Atp5mc2 ATP synthase membrane subunit c locus 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp5mc2provided by RGD
Official Full Name: ATP synthase membrane subunit c locus 2provided by RGD
Primary source: RGD:620051
See related: Ensembl:ENSRNOG00000015320 AllianceGenome:RGD:620051
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atp5g2
Summary: Enables ligand-gated channel activity. Involved in pore complex assembly; response to 3,3',5-triiodo-L-thyronine; and response to ethanol. Part of cation channel complex. Human ortholog(s) of this gene implicated in renal cell carcinoma and urinary bladder cancer. Orthologous to human ATP5MC2 (ATP synthase membrane subunit c locus 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 1941.0), Muscle (RPKM 1596.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (135669847..135680839, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133791341..133799713, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (144264207..144272578, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC130177P1 (e-PCR)
- UniSTS:270613

D12S2096 (e-PCR)
- UniSTS:31887

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ligand-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pore complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to 3,3',5-triiodo-L-thyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP synthase F(0) complex subunit C2, mitochondrial

Names: ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P2; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9); ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9); ATPase protein 9; ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133556.2 → NP_598240.1 ATP synthase F(0) complex subunit C2, mitochondrial precursor

See identical proteins and their annotated locations for NP_598240.1

Status: PROVISIONAL

Source sequence(s)

BC128726

UniProtKB/Swiss-Prot

A2VCW6, Q06646

UniProtKB/TrEMBL

A0A8I6AM76, A6KCX5

Related

ENSRNOP00000020675.3, ENSRNOT00000020676.7

Conserved Domains (1) summary

MTH00222
Location:67 → 141

ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

135669847..135680839 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262948.1 → XP_063119018.1 ATP synthase F(0) complex subunit C2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

A2VCW6, Q06646

UniProtKB/TrEMBL

A6KCX5
XM_039078345.2 → XP_038934273.1 ATP synthase F(0) complex subunit C2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

A2VCW6, Q06646

UniProtKB/TrEMBL

A0A8I6AM76, A6KCX5

Conserved Domains (1) summary

MTH00222
Location:67 → 141

ATP9; ATP synthase F0 subunit 9; Provisional