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Sult1c2 sulfotransferase family 1C member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171072, updated on 3-Apr-2024

Summary

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Symbol
Sult1c2provided by RGD
Full Name
sulfotransferase family 1C member 2provided by RGD
Primary source
RGD:621064
See related
Ensembl:ENSRNOG00000065530 AllianceGenome:RGD:621064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ST1C2; sultK1; rSULT1C2
Summary
Enables aryl sulfotransferase activity. Involved in sulfation. Located in lysosome. Orthologous to human SULT1C2 (sulfotransferase family 1C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Expression
Restricted expression toward (RPKM 2818.1) See more
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Genomic context

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Location:
9q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (7436981..7486894)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6824840..6848830)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (4654278..4685418, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase 1C2A-like Neighboring gene putative sperm motility kinase W Neighboring gene sulfotransferase family 1C member 2A like 1 Neighboring gene sulfotransferase family 1C member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. Rondini EA, et al. J Pharmacol Exp Ther, 2015 Dec. PMID 26427720, Free PMC Article
  2. Decreased sulfotransferase SULT1C2 gene expression in DPT-induced polycystic kidney. Sugimura K, et al. Kidney Int, 2002 Sep. PMID 12164856
  3. Enzymatic properties, tissue-specific expression, and lysosomal location of two highly homologous rat SULT1C2 sulfotransferases. Xiangrong L, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872834
  4. Expression of the sulfotransferase 1C family: implications for xenobiotic toxicity. Runge-Morris M, et al. Drug Metab Rev, 2013 Nov. PMID 24028175
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our findings demonstrate that cholesterol biosynthetic intermediates influence SULT1C2 expression in rat primary
    Title: Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112625, MGC124969

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sulfotransferase 1C2
Names
sulfotransferase 1C2-like
sulfotransferase K1
sulfotransferase family, cytosolic, 1C, member 2
NP_598231.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133547.6 → NP_598231.4  sulfotransferase 1C2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2JUM0, A0A8I6ARK1
    Conserved Domains (1) summary
    pfam00685
    Location:39 → 288
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    7436981..7486894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUW8.2 GenPept UniProtKB/Swiss-Prot:Q9WUW8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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