Akap5 A-kinase anchoring protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akap5provided by RGD
Official Full Name: A-kinase anchoring protein 5provided by RGD
Primary source: RGD:620829
See related: Ensembl:ENSRNOG00000006410 AllianceGenome:RGD:620829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P150; Akap79; AKAP150
Summary: Enables several functions, including SH3 domain binding activity; enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including nervous system development; regulation of adenylate cyclase activity; and regulation of metal ion transport. Located in several cellular components, including basolateral plasma membrane; cell projection membrane; and dendritic shaft. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human AKAP5 (A-kinase anchoring protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 1028.5) and Brain (RPKM 140.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (100787169..100796712)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (95051527..95061075)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (99356509..99361909)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction between A-kinase anchoring protein 5 and protein kinase A mediates CaMKII/HDAC signaling to inhibit cardiomyocyte hypertrophy after hypoxic reoxygenation.
Title: Interaction between A-kinase anchoring protein 5 and protein kinase A mediates CaMKII/HDAC signaling to inhibit cardiomyocyte hypertrophy after hypoxic reoxygenation.
A-kinase anchoring protein 5-ancored calcineurin regulates the remodeling of H9c2 cardiomyocytes exposed to hypoxia and reoxygenation.
Title: A-kinase anchoring protein 5-ancored calcineurin regulates the remodeling of H9c2 cardiomyocytes exposed to hypoxia and reoxygenation.
Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation.
Title: Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation.
This study suggest that HDAC-mediated targeting of BDNF and AKAP-dependent local signaling within VTA could provide novel therapeutics for prevention of later-life psychopathology.
Title: Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA.
AKAP150 is localized in astrocytes and is up-regulated during ischemia both in vitro and in vivo. Knock-down of AKAP150 by RNAi depolarizes the astrocytic membrane potential and substantially reduces by 80% the ability of astrocytes to take up extracellular potassium during ischemic conditions.
Title: A-Kinase-Anchoring Protein (AKAP150) is expressed in Astrocytes and Upregulated in Response to Ischemia.
Report coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining IK1 current function.
Title: Role of plasma membrane-associated AKAPs for the regulation of cardiac I(K1) current by protein kinase A.
Study shows that mGlu1/5 activation leads to phosphorylation of a specific TRPV1 residue via PKC and AKAP150 in trigeminal sensory neurons and that functional interactions between glutamate receptors and TRPV1 mediate muscle tissue mechanical hyperalgesia
Title: Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat.
knockdown of Akap5 blocked homeostatic scaling and thus synaptic plasticity.
Title: PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity.
Cardiac AKAP150 positively responds to hyperglycemia and enhances the efficiency of glucotoxicity signaling through a cPKC/p47(phox)/ROS pathway that induces myocardial dysfunction, cardiomyocyte apoptosis, and oxidative stress.
Title: AKAP150 mobilizes cPKC-dependent cardiac glucotoxicity.
a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells.
Title: Role of AKAP79/150 protein in β1-adrenergic receptor trafficking and signaling in mammalian cells.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GABA receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase binding	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables beta-2 adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-2 adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2B binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amylase secretion	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in clustering of voltage-gated calcium channels	ISO Inferred from Sequence Orthology more info
involved_in clustering of voltage-gated potassium channels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of monoatomic ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endosome to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic neurotransmitter receptor cycle	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in excitatory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic recycling endosome	ISO Inferred from Sequence Orthology more info
located_in postsynaptic recycling endosome	ISO Inferred from Sequence Orthology more info
located_in postsynaptic recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A-kinase anchor protein 5

Names: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 150 kDa; AKAP 150; AKAP-5; RII-B-binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133515.2 → NP_598199.2 A-kinase anchor protein 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P24587, P70593

Related

ENSRNOP00000094047.1, ENSRNOT00000119804.1

Conserved Domains (1) summary

pfam03832
Location:73 → 100

WSK; WSK motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

100787169..100796712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111734.2 → XP_038967662.1 A-kinase anchor protein 5 isoform X1

UniProtKB/Swiss-Prot

P24587, P70593

UniProtKB/TrEMBL

A0A8I6AK18, A6HCA2

Conserved Domains (2) summary

PTZ00121
Location:282 → 655

PTZ00121; MAEBL; Provisional

pfam03832
Location:79 → 107

WSK; WSK motif