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Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170919, updated on 2-May-2024

Summary

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Official Symbol
Agpat4provided by RGD
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 4provided by RGD
Primary source
RGD:619916
See related
Ensembl:ENSRNOG00000017731 AllianceGenome:RGD:619916
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phospholipid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system and mitochondrial outer membrane. Orthologous to human AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 133.0), Adrenal (RPKM 98.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (51075081..51181548, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48525131..48633798, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48716094..48826292, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099124 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mitogen activated protein kinase kinase kinase 4 Neighboring gene uncharacterized LOC108349099 Neighboring gene uncharacterized LOC134482716 Neighboring gene uncharacterized LOC134482715 Neighboring gene parkin RBR E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. Eto M, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333445
  2. Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Bradley RM, et al. Biochim Biophys Acta, 2015 Dec. PMID 26417903
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93227

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Names
1-AGP acyltransferase 4
1-AGPAT 4
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, delta)
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
LPAAT-delta
lysophosphatidic acid acyltransferase delta
NP_596897.1
XP_006227918.1
XP_006227919.1
XP_063128906.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133406.2 → NP_596897.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

    See identical proteins and their annotated locations for NP_596897.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q924S1
    UniProtKB/TrEMBL
    A0A8I6ALQ9, A6KJY8
    Related
    ENSRNOP00000024213.2, ENSRNOT00000024213.5
    Conserved Domains (1) summary
    PLN02380
    Location:20 → 326
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    51075081..51181548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006227857.5 → XP_006227919.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

    See identical proteins and their annotated locations for XP_006227919.1

    UniProtKB/Swiss-Prot
    Q924S1
    UniProtKB/TrEMBL
    A0A8I6ALQ9, A6KJY8
    Conserved Domains (1) summary
    PLN02380
    Location:20 → 326
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

  2. XM_006227856.5 → XP_006227918.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWH4, A0A8I6ALQ9
    Related
    ENSRNOP00000069883.1
    Conserved Domains (3) summary
    cd07990
    Location:98 → 292
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    COG0204
    Location:51 → 325
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam16076
    Location:279 → 350
    Acyltransf_C; Acyltransferase C-terminus

  3. XM_063272836.1 → XP_063128906.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924S1.1 GenPept UniProtKB/Swiss-Prot:Q924S1

Gene LinkOut

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