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Tesk2 testis associated actin remodelling kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170908, updated on 11-Apr-2024

Summary

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Official Symbol
Tesk2provided by RGD
Official Full Name
testis associated actin remodelling kinase 2provided by RGD
Primary source
RGD:619984
See related
Ensembl:ENSRNOG00000017282 AllianceGenome:RGD:619984
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including focal adhesion assembly; protein phosphorylation; and spermatogenesis. Located in cytoplasm and nucleus. Orthologous to human TESK2 (testis associated actin remodelling kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 57.4), Kidney (RPKM 36.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q35
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135415352..135507226)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130178715..130270594)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135574172..135659842)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 1 Neighboring gene metabolism of cobalamin associated C Neighboring gene coiled-coil domain containing 163 Neighboring gene ribosomal protein S26 like 4 Neighboring gene target of EGR1, exonuclease Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Røsok O, et al. Genomics, 1999 Oct 1. PMID 10512679
  2. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. Toshima J, et al. J Biol Chem, 2001 Aug 17. PMID 11418599
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity testis-specific protein kinase 2
Names
testicular protein kinase 2
testis-specific kinase 2
NP_596887.1
XP_038965137.1
XP_038965138.1
XP_038965139.1
XP_063143181.1
XP_063143182.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133396.2 → NP_596887.1  dual specificity testis-specific protein kinase 2

    See identical proteins and their annotated locations for NP_596887.1

    Status: PROVISIONAL

    Source sequence(s)
    AB049402
    UniProtKB/Swiss-Prot
    A1A5M5, Q924U5
    UniProtKB/TrEMBL
    A0A8I6A1L1, A6JZ94
    Related
    ENSRNOP00000023416.3, ENSRNOT00000023416.5
    Conserved Domains (1) summary
    cd14155
    Location:64 → 316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    135415352..135507226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109210.2 → XP_038965138.1  dual specificity testis-specific protein kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    A1A5M5, Q924U5
    UniProtKB/TrEMBL
    A0A8I6A1L1, A6JZ94
    Conserved Domains (1) summary
    cd14155
    Location:64 → 316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

  2. XM_039109209.2 → XP_038965137.1  dual specificity testis-specific protein kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    A1A5M5, Q924U5
    UniProtKB/TrEMBL
    A0A8I6A1L1, A6JZ94
    Conserved Domains (1) summary
    cd14155
    Location:64 → 316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

  3. XM_063287111.1 → XP_063143181.1  dual specificity testis-specific protein kinase 2 isoform X3

  4. XM_039109211.2 → XP_038965139.1  dual specificity testis-specific protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A1L1
    Conserved Domains (1) summary
    cd14155
    Location:32 → 276
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

  5. XM_063287112.1 → XP_063143182.1  dual specificity testis-specific protein kinase 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924U5.1 GenPept UniProtKB/Swiss-Prot:Q924U5

Gene LinkOut

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