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Parvb parvin, beta [ Mus musculus (house mouse) ]

Gene ID: 170736, updated on 11-Apr-2024

Summary

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Official Symbol
Parvbprovided by MGI
Official Full Name
parvin, betaprovided by MGI
Primary source
MGI:MGI:2153063
See related
Ensembl:ENSMUSG00000022438 AllianceGenome:MGI:2153063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D15Gsk1; affixin
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including actin cytoskeleton reorganization; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in several cellular components, including cell junction; cytoskeleton; and plasma membrane. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; liver; and sensory organ. Orthologous to human PARVB (parvin beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 18.6), lung adult (RPKM 17.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E2; 15 39.78 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84116244..84199890)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84232043..84315689)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_39354 Neighboring gene gamma-secretase subunit PEN-2 pseudogene Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene VISTA enhancer mm91 Neighboring gene STARR-seq mESC enhancer starr_39355 Neighboring gene STARR-seq mESC enhancer starr_39356 Neighboring gene predicted gene, 33723 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84146147-84146300 Neighboring gene predicted gene, 22890 Neighboring gene parvin, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Shibue T, et al. Cancer Cell, 2013 Oct 14. PMID 24035453, Free PMC Article
  2. Novel protein-protein interactions inferred from literature context. van Haagen HH, et al. PLoS One, 2009 Nov 18. PMID 19924298, Free PMC Article
  3. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Krüger M, et al. Cell, 2008 Jul 25. PMID 18662549
  4. Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. Matsuda C, et al. J Neuropathol Exp Neurol, 2005 Apr. PMID 15835269
  5. The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Thievessen I, et al. Curr Biol, 2022 Jul 25. PMID 35688156

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Parvins are critical for the organization of endothelial cell-cell junctions, the establishment of endothelial apical-basal polarity, and the integrity of the basement membrane.
    Title: Parvins Are Required for Endothelial Cell-Cell Junctions and Cell Polarity During Embryonic Blood Vessel Formation.
  2. Data from functional molecular imaging demonstrated that beta-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting that beta-parvin might be a crucial modulator of cell survival.
    Title: Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
  3. Data show that affixin is a dysferlin binding protein that colocalizes with dysferlin at the sarcolemma of normal skeletal muscle.
    Title: Dysferlin interacts with affixin (beta-parvin) at the sarcolemma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell projection assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity regulating cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-parvin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133167.3 → NP_573395.1  beta-parvin

    See identical proteins and their annotated locations for NP_573395.1

    Status: VALIDATED

    Source sequence(s)
    AK147758, AL626769
    Consensus CDS
    CCDS37167.1
    UniProtKB/Swiss-Prot
    Q9ES46
    UniProtKB/TrEMBL
    Q3UGT9
    Related
    ENSMUSP00000023072.7, ENSMUST00000023072.7
    Conserved Domains (1) summary
    pfam00307
    Location:89 → 190
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    84116244..84199890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520532.4 → XP_006520595.2  beta-parvin isoform X1

    Conserved Domains (1) summary
    pfam00307
    Location:51 → 158
    CH; Calponin homology (CH) domain

  2. XM_030248364.1 → XP_030104224.1  beta-parvin isoform X2

    Conserved Domains (1) summary
    pfam00307
    Location:36 → 143
    CH; Calponin homology (CH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES46.1 GenPept UniProtKB/Swiss-Prot:Q9ES46

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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